G1-2087. Streptococcus pneumoniae (Spn) Invasive Diseases: Surveillance of Serotypes in Children in Argentina
Session: Poster Session: Pneumococcal Vaccines: Pediatrics
Monday, October 27, 2008: 12:00 AM
Room: Hall C
Background: In 1993 the PAHO-SIREVA group organized a nationwide laboratory based surveillance system of invasive Spn infections in children in 6 Latin American countries, (actually 23). Aim: To identify invasive Spn serotypes (ST), changes through the time, representation in conjugated vaccines Methods: Prospective study. Surveillance period: 1994-2006. Inclusion criteria: Spn isolated from normally sterile sites in children < 6 y. old with invasive disease, admitted to 37 hospitals located in 22 cities representing all geographic regions, identified by standard procedures. Capsular serotyping: Quellung reaction. Statistical Analysis: Whonet 5.3 - EpiInfo 6.04 Results: Spn included: 2040. Age < 2 y. old: 67%. Diagnosis: pneumonia (P) 57.4%; meningitis (M) 26%; sepsis 8%; fever without focus 4%; other 3%. M and sepsis were prevalent in 1º year of life (p<.0001). ST founded 49; the main were (%): 14 (32.5); 5 (13.1); 1 (10.3); 6B (6.7); 7F (4.3); 9V (3.4); 19A (3.3) 23F (2.9); 18C (3.2). Comparing period 1994-2003 vs. 2004-06, few changes were observed: ST 14 decreased (35.3% vs. 25.8%), p < .0001; ST 1 increased (8.7% vs. 13.8%), p<.0001). Other ST without significant changes. ST 1 and 5 were less prevalent in children < than 2 y. old vs. > 2 y. old: 5.1% vs. 20.6%: OR: 0.21 (95% CI 0.15-0.28) p < .0001, and 10.2% vs. 19.0%: OR: 0.50 (95% CI 0.38-0.65) p<.0001, respectively; ST 14 was prevalent in children < than 2 years old (p<.0001). ST 1, 9V and 14 were prevalent in P vs. M. ST represented in conjugated vaccines: 7-V: 52.2%; 9-V: 75.6%; 10-V: 79.9%; 13-V: 86%. The 7-V shown a higher coverage in children < 2 y. old with P (67%). Conclusions: Continuous surveillance network was achieved. High proportion of ST 1 and 5 influenced moderate coverage of 7-V vaccine; the best coverage was observed for children < than 2 years old with P.
Alejandra Corso, Bioquemistry1, Luis Di Fabio, MD2, Mabel Regueira, biochemistry1, María Moscoloni, Bioquemistry1, Raúl Ruvinsky, MD3, Salvador Garcia, MD4, Sofia Fossati, Bioquemistry1 and  R. O. Ruvinsky, None., (1)ANLIS Malbran, (2)PAHO, (3)PAHO, Buenos Aires, Argentina, (4)Pan American Health Organization, Washington, DC


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