P-1601. Analysis of Nucleotide Polymorphisms of pvmdr1 in Breakthrough Plasmodium vivax in Korea
Session: Poster Session: Malaria and Babesia
Sunday, October 26, 2008: 12:00 AM
Room: Hall C
Background: Although the mechanism of P. vivax chloroquine resistance is unclear, it has been suggested that the mutation of pvmdr1 that is the orthologue of the pfmdr1 of Plasmodium falciparum related to the chloroquine resistance. We investigated pvmdr1 polymorphisms of P. vivax isolated from patients under chemoprophylaxis in the Republic of Korea (ROK) Army. Methods: From June 1 to September 30, 2006, we investigated the malaria patients who were admitted to the three referral Armed Forces Hospitals, located in the Northern Kyunggi province near the demilitarized zone. The pvmdr1 polymorphisms of breakthrough vivax malaria were analyzed using BLAST 2 Sequences of National Center for Biotechnology information databases. Results: We analyzed the pvmdr1 polymorphisms of 78 Plasmodium vivax isolates from the 85 available specimens among 102 malaria cases occurring during study period. The F1076L mutation of pvmdr1 was observed in all isolates including 63 isolates from patients with chloroquine prophylaxis failure. Conclusion: It was likely that the F1076L mutation of the pvmdr1 might contribute to chloroquine prophylaxis failure in P. vivax.
Changsoo Kim, MD, Yonsei University, Seoul, Korea, Republic of, Inho Park, MD, The Armed Forces Medical Command, Seongnam-si, Korea, Republic of, Jun Yong Choi, staff, Yonsei University College of Medicine, Seoul, Korea, Republic of, June Myung Kim, MD, AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea, Young Keun Kim, MD, PhD, Konyang University, Daejeon, Korea, Republic of and  Y. Kim, None.


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