D-1111. Utility of Quantiferon-tb In-Tube Test for Differentiating Active Tuberculosis from Latent Tuberculosis Infection, in an Intermediate Burden Country
Session: Poster Session: Laboratory Testing for Mycobacteria
Sunday, October 26, 2008: 12:00 AM
Room: Hall C
Background: The aim of the present study was to assess the contribution of a QuantiFERON-TB Gold In-Tube test (QFT-IT) to the differentiation of active tuberculosis (TB) from latent tuberculosis infection (LTBI) by quantifying interferon-γ levels. Methods: We retrospectively reviewed clinical records from 314 patients older than 15 years who had QFT-IT performed between July 2006 and August 2007 at Severance Hospital, Yonsei University College of Medicine. Results: Subjects with active TB and positive results of QFT-IT (n=66) and LTBI (n=76) were included. Mean ±SD IFN-γ levels were: 6.06±3.59 (range 0.56 ~ 10) for subjects with active TB; 4.11±3.57(range 0.35 ~ 10) for subjects with LTBI. the quantitative results of the QFT-IT of subjects with active TB were different from that of LTBI with stastical significance.(P =0.001) Conclusion: Although production of IFN-γ, measured by QFT-IT correlated to some extent with activity of Mycobacterium tuberculosis infection, measuring IFN-γ using QFT-IT might not be useful for distinguishing active from LTBI because of the overlap of the quantitative results of the QFT-IT between subjects with active TB and LTBI.
Bum Sik Chin, MD1, Chang Oh Kim, Fellow2, Han Sung Lee3, Hee Kyung Choi, MD4, Jun Yong Choi, staff2, June Myung Kim, MD5, Myung Soo Kim, MD6, Sang Hoon Han, MD5, Su Jin Jeong, Resident2, Suk Hoon Choi, Fellowship7, Young Goo Song, MD8 and  S. Choi, None., (1)Yonsei University Medical Center, Seoul, Korea, Republic of, (2)Yonsei University College of Medicine, Seoul, Korea, Republic of, (3)Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, (4)Yonsei university college of medicine, Seoul, Korea, Republic of, (5)AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea, (6)KwangMyung SungAe Hos, KwangMyung, Korea, Republic of, (7)Yonsei university collage of medicine, Department of Internal Medicine, Seoul, Moldova, Republic of, (8)Yonsei Univ. Coll. of Med., Seoul, Korea, Republic of