M-1845. Zygomycosis in Europe: A Prospective, Epidemiologic Study
Session: Slide Session: Clinical Mycology
Monday, October 27, 2008: 12:00 AM
Room: Room 145A
Background: Zygomycosis has emerged as an important mould infection with a high mortality. The aim of this study was to analyze its epidemiology in Europe. Methods: In each country, a national co-ordinator prospectively collected zygomycosis cases recorded on specially provided case report forms that were centrally evaluated by the study co-ordinator. The study started in Jan 2005 and lasted 3 yrs. Statistical analysis was performed with SPSS v.12. Results: Thirteen countries enrolled 212 patients. Mean age was 50 yrs (range 1-87) and male gender 61%. Most common underlying conditions were hematological malignancies (53%), trauma (15%) and diabetes mellitus (10%). The main sites of infection were rhinocerebral (29%), pulmonary (27%), soft tissue (24%) and disseminated (17%). The isolated fungi were Rhizopus spp. (32%), Mucor spp. (31%), Absidia spp. (20%), and others (17%). 51% of patients received only amphotericin B formulations, 6.3% only posaconazole and 31.6% received both. Mortality was 47.8%. On multivariate analysis, factors influencing outcome were surgical treatment (p<0.001), age (p=0.037), non-trauma related infection (p=0.022) and previous use of corticosteroids (p=0.035). Conclusions:
1. The main clinical presentations were rhinocerebral, pulmonary and soft tissue infections, while Mucor and Rhizopus spp. were isolated at similar rates. 2. Outcome is dismal in half cases and is significantly better when trauma is the predisposing factor or when surgical treatment is applied.
GROUP ON Zygomycosis European Confederation of MEDICAL Mycology WORKING, Andreas Groll, Childrens Hospital, Anna Skiada, MD, University of Athens, Athens, Greece, Bertrand Dupont, MD, PhD, Institut Pasteur, Cornelia Lass-Floerl, University of Innsbruck, Emilio Bouza, MD, PhD, Hosp. General Gregorio Maranon University of Madrid, Madrid, Spain, Emmanuel Roilides, PhD, Hippokration Hospital, Thessaloniki, Greece, George Petrikkos, MD, PhD, 4th Internal Medicine and Infectious Diseases Department, Attikon University General Hospital,Univ of Athens Med Sch, Athens, Greece, Jacques Meis, Canisius Wilhelmina Hospital, Livio Pagano, Prof, University Cattolica del Sacro Cuore, Michael Aoun, Institut J Bordet, Stefan Zimmerli, University of Bern and  A. Skiada, None.

Emilio Bouza
Microbiology and Infectious Disease Division, Hospital "Gregorio Marañón", University of Madrid, Spain
Emilio Bouza is currently the Director of the Microbiology and Infectious Disease Division at the Hospital "Gregorio Marañón" in Madrid. He is also a Full Professor of Microbiology and Infectious Diseases at the University of Madrid, Spain.
Dr. Bouza is a founding member and former president of the Spanish Society for Clinical Microbiology and Infectious Diseases (SEIMC) and has also held several positions within the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), including Member Elect of the Executive Committee, Founder and First Head of the Study Group of Nosocomial Infections (ESGNI) and Secretary General of the Society. He was the Editor in Chief of Clinical Microbiology and Infectious Diseases for a period of 4 years,
Dr. Bouza has authored more than 350 indexed publications and is author of over 100 book chapters. His research interests lie in the diagnosis and treatment of nosocomial infections including invasive fungal infections, catheter-related bloodstream infections, endocarditis, nosocomial pneumonia and Clostridium difficile-associated diarrhea,

Iosifidis P. Ilias (Elias), MD, MSc
Education
Oct.2003-Oct.2005: Postgraduate Studies (MSc) in Medical Research Methodology (Children’s Health Field), Medical School, Aristotle University of Thessaloniki, Degree: Excellent
1997-2002: Medical School, Aristotle University of Thessaloniki, Greece, Degree (Ptychio) Iatrikes: Very good
Current post
April 2009- now: Senior House Officer in Pediatrics, 3rd Pediatric Department, Aristotle University of Thessaloniki, Hippokratio General Hospital, Greece
Previous Experience
Jan 2007- March 2009: Postgraduate Studies, Laboratory of Infectious Diseases, Laboratory of Infectious Diseases, 3rd Pediatric Department, Aristotle University of Thessaloniki, Hippokratio General Hospital, Greece
Dr. T. Papastaurou, Dr. E. Roilides
Nov 2009-Dec 2009: Scientific observer in Children’s Hospital of Philadelphia (CHOP), Pediatric Infectious Disease Department, CHOP, PA, USA
Sep 2006 -Dec 2006: Senior House Officer in Neonatology, Neonatal Intensive Care Unit, Papageorgiou General Hospital, Thessaloniki, Greece, Dr. N. Nikolaidis
Feb 2005 - Aug 2006: Senior House Officer in Pediatrics, Pediatric Department, Infectious Disease Hospital, Thessaloniki, Greece, Dr. I. Kavaliotis
Feb 2004-Feb 2005: Research Associate in Pediatric Department and Laboratory of Infectious Diseases
Laboratory of Infectious Diseases, 3rd Pediatric Department, Aristotle University of Thessaloniki, Ippokratio General Hospital, Greece, Dr. I. Tsiouris, Dr. E. Roilides
Sep 2002-Dec 2003: Compulsory Medical Service (countryside doctor), Health Center of Skidra, Edessa, Greece
General Hospital of Edessa, Greece
Research- Articles
1) Filioti I, Iosifidis E, Roilides E. Therapeutic strategies for invasive fungal infections in neonatal and pediatric patients. Expert Opin Pharmacother, 2008;9:3179-96
2) Iosifidis E, Antachopoulos C, Tsivitanidou M, Katragkou A, Farmaki E, Tsiakou M, Kyriazi T, Sofianou D, Roilides E. Differential Correlation Between Rates of Antimicrobial Drug Consumption and Prevalence of Antimicrobial Resistance in a Tertiary Care Hospital in Greece. Infect Control Hosp Epidemiol, 2008; 29: 615-22
3) Dotis J, Iosifidis E, Roilides E. Central nervous system aspergillosis in children: a systematic review of reported cases. Int J Infect Dis 2007; 11: 381-93
Research- Presentations
1) PP. Tsitsopoulos, E. Iosifidis, C. Antachopoulos, I Anagnostopoulos, M. Tsivitanidou. E. Roilides, PD. Tsitsopoulos. Nosocomial bloodstream infections in neurosurgical patients. A 5-year study. 19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki, Finland, May 2009
2) Kantziou K, Iosifidis E, Chatzimoschou A, Georgiadou E, Antachopoulos C, Roilides E. Performance of an in-vitro interferon-gamma release assay (IGRA) and tuberculin sensitivity test (TST) for the diagnosis of tuberculosis. 26th Annual meeting of the European Society for Paediatric Infectious Diseases congress, Graz, Austria, May 2008
Congresses
48th annual ICAAC/IDSA 46th annual meeting
15th International Symposium on Infections in the Immunocompromised Host (ICHS),
26th Annual Meeting of the European Society for Paediatric Infectious Diseases,
15 to 18th European Congress of Clinical Microbiology and Infectious Diseases



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