B-072. Fecal Carriage of K1 Serotype Klebsiella pneumoniae with ST23 in Healthy Adults in Korea
Session: Poster Session: Virulence Mechanisms of Bacterial Pathogens
Saturday, October 25, 2008: 12:00 AM
Room: Hall C
Background: Recent nationwide study in Korea showed K1 serotype Klebsiella pneumoniae with ST23 is responsible for increasing incidence of K. pneumoniae liver abscess in this country. We investigated the fecal carriage rate of K1 K. pneumoniae in the healthy adults in Korea and the ST profiles of these strains. Methods: A total of 1,032 stool specimens of adults were collected through health screening programs in 10 university-affiliated hospitals in Korea. K. pneumoniae strains were selected using MCIK (MacConkey-inositol-potassium tellurite) media and then identified. K1 serotype was determined by PCR for magA. MLST was performed for K. pneumoniae strains with K1 serotype and ST was determined using the PubMLST database. Results: K. pneumoniae was isolated from 185 (17.9%), among which 50 (27%) were determined to be K1 serotype. MLST revealed that 47 (94%) out of K1 K. pneumoniae strains belonged to ST23, and three strains were new sequence types. Reference strains with K1 serotype (ATCC 8045, 8047, 13886, 35593 and 8044) were all ST82.
Conclusions: This study clearly shows that K1 K. pneumoniae strains with ST23, major causative agents of liver abscess in Korea, are common colonizers found in intestinal tract of the healthy adults in Korea. It may partially explain high prevalence of liver abscess by these strains in Korea.
Chisook Moon, MD, Doo Ryeon Chung, MD2, Harim Lee, MS3, Hyun Ha Chang, MD, PhD4, Jae-Hoon Song, MD2, Jinyang Baek, MS5, Jun Seong Son, MD, PhD6, Ki Tae Kwon, MD7, Kwan Soo Ko, PhD8, Kyong Ran Peck, MD8, Sang Yop Shin, MD7, Seong Yeol Ryu, M.D9, Shin-Woo Kim, MD, Sook In Jung, MD10, Yeon-Sook Kim, MD11 and  H. Lee, None., (1)Division of Infectious Diseases, Samsung Medical Center, Seoul, South Korea, (2)ARFID, (3)Kyungpook National University Hospital, Daegu, South Korea, (4)Asian-Pacific Research Foundation for Infectious Diseases (ARFID), (5)Kyunghee University Hospital, (6)Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, (7)Samsung medical center, Seoul, Korea, Republic of, (8)Infectious disease, Keimyung University Dongsan Medical Center, Daegu, South Korea, (9)Chonnam national university medical school, Gwangju, Korea, Republic of, (10)Chungnam National University Hospital