K-1373. Trends of Antimicrobial Resistance of Blood Isolates from Patients in a Public Tertiary Hospital in Greece
Session: Poster Session: Antibiotic Use and Resistance
Sunday, October 26, 2008: 12:00 AM
Room: Hall C
Background: Advanced antimicrobial resistance has become one of the most important problems in clinical practice worldwide during the recent years.
Methods: Data on isolates from cultures of blood specimens from patients hospitalized in a public tertiary hospital in Greece for the period 1/1/1998-31/12/2005 as well as their in vitro antimicrobial susceptibility pattern were retrospectively collected and analyzed. Results: Gram-positive bacteria were more common than Gram-negative bacteria or fungi throughout the study period [2047/3316 (61.7%), 1206/3316 (36.4%), and 63/3316 (1.9%), respectively]. The most commonly isolated microorganisms were: coagulase-negative staphylococci (44.8%), Escherichia coli (17%), Staphylococcus aureus (11.1%), Klebsiella pneumoniae (4.9%), Enterococcus faecalis (4%), Pseudomonas aeruginosa (4%), and Proteus mirabilis (3.7%). Regarding the secular changes of the antimicrobial resistance during our study there was only one statistically significant change; resistance of S. epidermidis isolates to oxacillin varied from 42.8% (1999) to 72.2% (2004) (p<0.001). More than 60% of S. aureus blood isolates were methicillin-resistant strains.
Conclusion: Even though the proportion of resistance was high in isolates of specific bacterial species, non-statistically significant differences were observed among the isolated microorganisms and their resistance pattern (except for S. epidermidis), when tested with different drugs, during the last 8 years (1998-2005) in this particular setting.
Alexandra Bakossi, MD1, Archontoula Karle1, Dimitra Petropoulou, MD1, Fotinie Ntziora, MD2, Matthew Falagas, MD, MSc, DSc2, Paraskevi Karle, MD1, Pierros Cholevas, MD3 and  M. E. Falagas, None., (1)Department of Microbiology, Nikaia General Hospital, Piraeus, Greece, (2)Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece, (3)Department of Opthalmology, Tzaneio General Hospital, Piraeus, Greece


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