Session: Poster Session: Human Pharmacokinetics/Dynamics
Monday, October 27, 2008: 12:00 AM
Room: Hall C
Background: Both obesity and the underweight state have been thought to predispose to the acquisition of various types of infections. Whether the outcomes of infections differ by body weight category has not been adequately studied. Methods: Studies reporting data on the outcomes of patients with bacterial infections with regard to body weight category were identified through searching PubMed, the Cochrane Central Register of Controlled Trials and bibliographies of relevant articles. Results: Eleven studies (10 prospective cohort studies) were included in this review involving a total of 3339 patients. Seven studies showed an association of patient outcomes (mortality in 6/7 studies) with body weight categories. This was shown in multivariate analyses in 4 of the 5 studies that reported relevant data. Obese or morbidly obese patients with infections had worse outcomes compared to all other body weight groups combined or to normal weight patients, in 4 of the 7 studies that reported relevant data; findings were not significant in the remaining 3 studies. Patients with a low body mass index (BMI) had worse outcomes compared to all other BMI groups combined, in 3 of the 5 studies that reported relevant data; findings were not significant in the remaining 2 studies. Low BMI was associated with worse outcomes in patients with lower respiratory tract infections in 3 of the 4 relevant studies. Conclusions: Although not consistently reported, an association of both ends of the distribution of body weight with worse outcomes of patients with infections might exist, and merits further investigation.
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