697. Molecular Epidermiology of Norovirus Patient with Acute Gastroenteritis in Northern Gyeonggi Province, South Korea
Session: Abstracts: Virology
Friday, October 22, 2010
Background: Norovirus is the most common cause of acute non-bacterial gastroenteritis in humans. Norovirus genus is a member of the family Caliciviridae, which is transmitted by food and water or from human to human. Many genotypes of genogroup I and II have been reported, because of high genetic diversity.

Methods: A total of 1,689 stool specimens collected from patient with acute gastroenteritis in northern Gyeonggi province of Korea during 2008 were analyzed by using RT-PCR followed by sequencing.

Results: Of the 1,689 specimens, norovirus, rotavirus, adenovirus and astrovirus were detected in 183 (10.8%), 188 (11.1%), 30 (1.8%) and 3 specimens (0.2%), repectively. The norovirus incidence was found to be the highest in January (28.6%), followed by November (22.1%) and December (20.8%). Norovirus infections were most frequently shown in the < 5 years old (73.8%). Norovirus positive specimens between males and females were 99 (54.1%) and 84 specimens (45.9%). Norovirus GI was detected in 27 specimens (1.6%) and GII in 156 specimens (9.2%). Based on partial sequence of capsid region, norovirus was resolved into 6 genotypes of genogroup I and 7 genotypes of genogroup II. The prevalent genotypes among gastroenteritis patients within the nothern Gyeonggi province were GII.4 (68.9%), GII.3 (13.1%) and GI.11 (7.1%).

Conclusion: This study shows the occurrence and diversity of noroviruses patient presenting acute diarrhea. The highest rates of norovirus infection were in children younger than 5 years of age. Norovirus-associated gastroenteritis occurs frequently during winter. GII.4 was the predominant genotype of the detected norovirus. Norovirus is responsible for the majority of epidemics in northern Gyeonggi province of Korea. The detected noroviruses belonged to two distinct genogroups, namely, GI and GII, and these represented 14.7% and 85.3%, respectively. These findings were concordant with previous epidermiological studies conducted worldwide; GI was consistently present at low incidence in fecal specimens compared to GII. Thus, continuous monitoring of the genetic diversity of norovirus is important to determine the trend of genotype.


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Speakers:
Kyong-Shin Ryu , North branch, Gyeonggi-do Institute of Health and Environment, Uijeongbu-si, South Korea
Seon-Jae Bang , North branch, Gyeonggi-do Institute of Health and Environment, Uijeongbu-si, South Korea
Yeon-Ok Kwon , North branch, Gyeonggi-do Institute of Health and Environment, Uijeongbu-si, South Korea
Sung-Hee Park , North branch, Gyeonggi-do Institute of Health and Environment, Uijeongbu-si, South Korea
Soo Jung Nam , North branch, Gyeonggi-do Institute of Health and Environment, Uijeongbu-si, South Korea
Kwang-Hee Park , North branch, Gyeonggi-do Institute of Health and Environment, Uijeongbu-si, South Korea

Disclosures:

K. S. Ryu, None

S. J. Bang, None

Y. O. Kwon, None

S. H. Park, None

S. J. Nam, None

K. H. Park, None

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