676. Chronic Co-Morbid Conditions as Risk-Factors for Herpes Zoster (HZ) in the United States, 2007
Session: Abstracts: Virology
Friday, October 22, 2010
Background: Approximately 30% of the population will develop HZ during life, but risk factors for the disease are poorly understood. We postulated that prevalent chronic medical conditions could contribute to the risk of HZ.

Methods: We conducted a case-control study using 2007 MarketScan data to investigate chronic medical conditions as risk factors for HZ among persons 17 to 64 years old. Cases were enrollees with a HZ diagnosis (ICD-9-CM codes 053.xx) and controls were those without a HZ diagnosis, matched by age groups and insurance plan.  We selected 13 common chronic conditions based on their prevalence or hypothesized association with HZ.  We calculated the attributable risk and created a co-morbidity composite by summing the adjusted odds ratios (OR) of significant conditions. We used unconditional logistic regression to evaluate the associations between HZ and co-morbid conditions.  

Results: We identified 65,604 cases and 659,768 controls. Twelve of 13 chronic conditions were more common among HZ cases with adjusted OR’s ranging from 1.05 to 1.50 (p<0.05).  The attributable risks for these conditions were small, ranging from 0.03% to 5%.  Cases were more likely to have > 4 co-morbid conditions than controls (adjusted OR 1.95, 95% CI 1.88 - 2.03), especially for younger age groups (OR 3.39 in 20-29 years vs. 1.94 in 60-64 years).

Conclusion: Prevalent chronic medical conditions may not contribute substantially to the risk of HZ in the population.  However, presence of multiple co-morbid conditions may increase the risk of HZ across all age groups, especially in young adults. 


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Speakers:
M. Riduan Joesoef, MD , Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA
Rafael Harpaz, MD, MPH , Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA
Jessica Leung, MPH , Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA
Stephanie R. Bialek, MD, MPH , Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA

Disclosures:

M. R. Joesoef, None

R. Harpaz, None

J. Leung, None

S. R. Bialek, None

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