699. Prevalence of WU and KI Polyomaviruses in Pediatric Hematology/Oncology Patients with Acute Respiratory Tract Illness
Session: Abstracts: Virology
Friday, October 22, 2010
Background:

Since their discovery in 2007, WU and KI polyomaviruses have been detected in respiratory specimens from children and adults worldwide.  Given the association with polyomaviruses causing more significant disease in immunocompromised patients, this study compares the prevalence and viral load of these viruses in hematology/oncology patients with symptomatic controls. 

Methods:

Respiratory specimens from hematology and oncology pediatric patients collected at The Children’s Hospital, Aurora, Colorado from 2008 to 2009 were tested by Real-Time Quantitative PCR for WU and KI.  These were compared with immunocompetent patients with respiratory illness.  Prevalence rates, viral loads and co-detection rates were determined.

Results:

The prevalence of WU in the immunocompromised population was 5/161 (3%) versus 14/295 (5%) in the control population (P = 0.5), and 9/161 (5.6%) versus 7/295 (2.3%) respectively for KI (P = 0.13).  There was a higher KI viral load for the immunocompromised group compared with the immunocompetent group (geometric mean of 6.6e6 copies/cell versus 3.1e4 copies/cell, P = 0.019). There was also a lower viral load for KI compared to WU in the control group (3.10e4 copies/cell versus 1.73e8 copies/cell, P = 0.001).  There was no statistically significant difference between viral load in both groups for WU.

Conclusion:

Because the overall prevalences of WU and KI were not different between immunocompromised patients and symptomatic controls without immunodeficiency, we conclude that acute infection is similar in these groups.  In future studies, viral load should be considered as a correlate for possible pathology from these viruses.


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Speakers:
Suchitra Rao, MB, BS , Pediatrics, University of Colorado School of Medicine, Aurora, CO
Robert L. Garcea, MD , Molecular Cellular and Developmental Biology, University of Colorado, Boulder, CO
Christine C. Robinson, PhD , Virology, The Children's Hospital, Aurora, CO
Eric A.F. Simoes, MD, DCH , Pediatrics-Infectious Diseases, The Children's Hospital, Aurora, CO

Disclosures:

S. Rao, None

R. L. Garcea, None

C. C. Robinson, None

E. A. F. Simoes, None

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