706. Association Between Kawasaki Disease and Acute Respiratory Viral Infections
Session: Abstracts: Virology
Friday, October 22, 2010
Background:

The etiology of Kawasaki disease (KD) is still unknown. But, broad spectrum of infectious agents have been found at diagnosis of KD. Recently, an association between human coronavirus NL63 (HCoV-NL63) and KD was implicated. Hence, we attempted to determine the association between KD and acute respiratory viral infections including HCoV-NL63.

Methods:

Nasopharyngeal aspirate samples were obtained from 54 patients diagnosed with KD at the Seoul National University (SNU) Children’s Hospital and SNU-Bundang Hospital between October 2003 and September 2006. Viral diagnoses of 11 respiratory viruses were made using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR): respiratory syncytial virus (RSV), adenovirus, rhinovirus (RV), parainfluenza viruses (PIVs) 1 and 3, influenza viruses (IFVs) A and B, human metapneumovirus (HMPV), human bocavirus (HBoV), HCoV OC43/229E, and HCoV-NL63. Clinical data were reviewed retrospectively.

Results:

The median age was 32 months (6 months-10.4 years). Respiratory symptoms were observed in 37 patients (69%). The following respiratory viruses were identified in 12 patients (22%): RV (n=4), PIV-3 (n=2), HBoV (n=2), and adenovirus, RSV, PIV-1, IFV-A, and HCoV-NL63 (n=1). Co-infection with PIV-3 and RV was observed in one patient. Respiratory symptoms were observed in 7 (58.3%) and 30 (71.4%) patients of the virus-positive and virus-negative groups (P>0.05). Response rate to intravenous immunoglobulin administration was 67% (n=8) and 86% (n=36) in the virus-positive and virus-negative groups (P >0.05).

Conclusion:

In this study, we showed that 22% of patients with KD had documented respiratory viral infections. Respiratory symptoms were commonly observed in KD patients but the association between respiratory viruses including HCoV-NL63 and KD were not found. Large multicenter-based investigations are required to confirm the association between acute respiratory viral infections and KD.


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Speakers:
Ki Wook Yun, MD , Pediatrics, Seoul National University Children`s Hospital, Seoul, South Korea
Ki Bae Hong, MD , Pediatrics, Seoul National University Children`s Hospital, Seoul, South Korea
Eun Young Cho, MD , Pediatrics, Seoul National University Children`s Hospital, Seoul, South Korea
Mi Ae Yang, MD , Pediatrics, Seoul National University Children`s Hospital, Seoul, South Korea
Jin Hyoung Choi, MD , Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea
Jina Lee, MD , Seoul National University Bundang Hospital, Gyeongido, South Korea
Eun Hwa Choi, MD , Pediatrics, Seoul National University Children`s Hospital, Seoul, South Korea
Hoan Jong Lee, MD , Seoul National University College of Medicine, Seoul, South Korea

Disclosures:

K. W. Yun, None

K. B. Hong, None

E. Y. Cho, None

M. A. Yang, None

J. H. Choi, None

J. Lee, None

E. H. Choi, None

H. J. Lee, None

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