687. Geographical Variation of HPV Infection Rates in a Sample of 1728 Women in Greece
Session: Abstracts: Virology
Friday, October 22, 2010
Background:

We examined the geographic distribution of HPV infection in a molecular epidemiology study of HPV infection in Greece prior to the implementation of HPV vaccination

Methods:

All women consecutively examined at the outpatient gynecological clinic of 10 health care centers across Greece were included. Liquid based cytology was performed and HPV DNA was detected with the use of Papillomavirus Clinical Arrays kits (CLART(R) HPV, Genomica).

Results:

Up to December 2007, 1728 women (mean age 41.4 ± 13.3 yrs) were examined and had fully evaluable cytological results. The prevalence of HPV infection was 49% (95% CI: 47%-50.9%). The prevalence of the most frequently identified HPV genotypes were, HPV 53:  9.3% (95%CU 8.2%-10.5%), HPV 66: 9.1% (95%CI 8.1%-10.4%), and HPV 51: 9.1% (95%CI 8%-10.3%), HPV 16 genotype had a prevalence of 6.8% (95% CI: 5.9%-7.9%), and HPV 18 a prevalence of 3.7%, 95%CI: 3%-4.5%). HPV DNA positivity for any genotype was higher in Southern Greece compared to Northern Greece participating centers (OR: 1.36, 95%CI 1.12-1.65, p=0.002). The difference concerned high risk oncogenic HPV genotypes (OR 1.33, 95%CI: 1.09-1.6, p = 0.005) and was also associated with increased rates of LGSIL in thin-prep Pap test (OR 1.5, 95% CI: 1.08-2.1, p  = 0.016) but not HGSIL (OR 1.86 , 95%CI 0.83-4.2,p=0.17).

Conclusion:

Rates of HPV infection including high risk types were higher in Southern compared to Northern Greece and were associated with cytological changes. Geographical variation within countries should be taken into account in future vaccination strategies.


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Speakers:
Sotirios Tsiodras, MD , 4th Dpt of Internal Medicine, University of Athens Medical School, Athens, Greece
Aris Spathis, PhD , Dpt of Diagnostic Cytology, University of Athens Medical School, Athens, Greece
Aikaterini Chranioti, PhD , Dpt of Diagnostic Cytology, University of Athens Medical School, Athens, Greece
John Panayiotides, MD , 2nd Dept of Pathology, University of Athens Medical School, ,Athens, Greece
Asimakis Pappas, MD , 3rd Dept of Obstetrics and Gynecology, University of Athens Medical School, Athens, Greece
Dimitrios Kassanos, MD , 3rd Dept of Obstetrics and Gynecology, University of Athens Medical School, Athens, Greece
Konstantinos Leventakos, MD , 4th Dpt of Internal Medicine, University of Athens Medical School, Athens, Greece
George Petrikkos, MD , 4th Dpt of Internal Medicine, University of Athens Medical School, Athens, Greece
Petros Karakitsos, MD , Cytopathology, University of Athens School of Medicine, Athens, Greece

Disclosures:

S. Tsiodras, None

A. Spathis, None

A. Chranioti, None

J. Panayiotides, None

A. Pappas, None

D. Kassanos, None

K. Leventakos, None

G. Petrikkos, None

P. Karakitsos, None

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