702. Clinical Correlates of WU and KI Polyomavirus Infection in Filipino Children
Session: Abstracts: Virology
Friday, October 22, 2010
Background:

WU and KI are recently discovered polyomaviruses whose clinical significance remains unknown.  We determined the prevalence and viral load of KI and WU in patients presenting with lower respiratory tract infections (LRTI) and correlated detection with clinical, radiographic, and laboratory findings.

Methods:

Specimens were collected in the context of a randomized, placebo-controlled pneumococcal vaccine trial in the Philippines.  1077 nasal wash samples from patients aged 6 months to 5 years who developed LRTIs were analyzed using qPCR for WU and KI.  Clinical information from the study was correlated with PCR findings.

Results:

The prevalences were 57/1077(5.3%) for WU and 45/1077(4.2%) for KI, and co-detection rates with other respiratory viruses were similar, 73.7%(WU) and 84.4%(KI). Viruses were detected primarily from inpatient samples: 54/57(94%) for WU, and 36/42(86%) for KI.  There was a higher KI viral load (VL) observed in inpatients compared with outpatients (geometric mean (GM) VL of 1.42e6 versus 2.38e4, P = 0.0042), but no difference was observed for WU.

Chest radiograph changes were seen in 28.3%(15/53) of WU and 27.9%(12/43) of KI infections. There was a significant difference in VL among those infections with infiltrates (GMVL 2.98X108 copies/cell versus 4.93 X106, P = 0.02 for WU, and 5.81 X106, copies/cell versus 7.29 X106, copies/cell, P = 0.04 for KI).

Conclusion:

WU and KI prevalences and co-detection rates were similar to previous reports. There was an association between VL and the presence of a pulmonary infiltrate, and inpatient status, although no association was seen with overall illness severity.


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Speakers:
Suchitra Rao, MB, BS , Pediatrics, University of Colorado School of Medicine, Aurora, CO
Marilla G. Lucero, MD, PhD , Research Institute for Tropical Medicine, Alabang, Philippines
Hanna Nohynek, MD, PhD , Department of Vaccines and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland
Gail Williams, PhD , School of Population Health, University of Queensland, Brisbane, Australia
Robert L. Garcea, MD , Molecular Cellular and Developmental Biology, University of Colorado, Boulder, CO
Eric A.F. Simoes, MD, DCH , Pediatrics-Infectious Diseases, The Children's Hospital, Aurora, CO

Disclosures:

S. Rao, None

M. G. Lucero, None

H. Nohynek, None

G. Williams, None

R. L. Garcea, None

E. A. F. Simoes, None

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