1370. Murder on the HIV Express: New Insights into How CD4 T Cells Die
Session: Symposium: Viruses: Bedside to Bench
Saturday, October 22, 2011: 6:15 PM
Room: 253ABC
This presentation will provide new perspectives on how HIV depletes CD4 T cells, highlighting how an innate immune response against abortive infection by the virus mediates killing. This presentation will further discuss an intriguing link between CD4 T cell death and inflammation that could distinguish pathogenic and non-pathogenic lentiviral infections.

Warner C. Greene, MD, PhD, Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, CA

Warner C. Greene, M.D., Ph.D., is the Director of the Gladstone Institute of Virology and Immunology and Professor of Medicine and of Microbiology and Immunology at the University of California, San Francisco.
After completing a B.A. (with greatest distinction) at Stanford University in 1971, Dr. Greene began his medical and research training in the Medical Scientist in Training Program at Washington University School of Medicine in St. Louis, where he received his M.D. and Ph.D. in 1977. For the next two years, he continued his studies as an intern and resident in internal medicine at the Massachusetts General Hospital in Boston. In 1979, he became an Investigator and later Senior Investigator in the Metabolism Branch of the National Cancer Institute. During his time at NCI, Dr. Greene molecularly cloned and characterized the alpha chain of the human interleukin-2 receptor and investigated deregulated expression of this receptor in HTLV-I induced adult T cell leukemia. In 1987, Dr. Greene was named Professor of Medicine at Duke University School of Medicine and Investigator in the Howard Hughes Medical Institute. At Duke, Dr. Greene’s laboratory began to study transcriptional regulation of HIV and the function of this virus’ regulatory gene products. In 1992, Dr. Greene was recruited to establish a new AIDS research center built by the State of California at UCSF and privately endowed by the J. David Gladstone Foundation.
As founding director of the Gladstone Institute of Virology and Immunology, Dr. Greene has overseen the establishment of an institute that has gained an international reputation for its studies of HIV and AIDS. His own research interests are focused on deciphering the molecular mechanisms that underlie replication of the virus and development of pathogenic effects. Ongoing studies are actively exploring the functions of the vif, vpr, rev, and nef auxiliary viral gene products and the roles of the NF-kB/Rel family of transcription factors and their cytoplasmic inhibitors in the viral life cycle.
The author of more than 280 scientific papers, the impact of Dr. Greene’s work is evidenced by his recognition as one of the 100 most-cited scientists in the world. He was also the recipient of the Outstanding Investigator Awards from the American Federation for Clinical Research and the American College of Rheumatology. Dr. Greene also serves as Co-Director of the UCSF-GIVI Center for AIDS Research.

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