1179. Mycobacterial Infections in a Large Virginia Hospital, 2001-2009
Session: Poster Abstract Session: Mycobacteria Other Than Tuberculosis
Saturday, October 22, 2011
Room: Poster Hall B1
Background: In areas where both tuberculosis (TB) and non-tuberculous mycobacteria (NTM) are prevalent, descriptive studies of the clinical features of individual mycobacteria are needed to create prediction tools and inform clinical triage.

Methods: We queried the University of Virginia Clinical Data Repository for all mycobacterial infections from 2001-2009.

Results: Of 494 mycobacterial infections in 467 patients there were 22 species. A pulmonary mycobacterial infection in an immigrant had a post-test probability of 82% for TB. Review of chest CT scans revealed that TB infection was more likely to exhibit cavities and pleural effusion than NTM infection. Among NTM infections M. kansasii, M. xenopi, and M. fortuitum were more likely than MAC to have cavities. There were at least 83 patients that met criteria for NTM lung disease and these were caused by 9 species. M. abscessus infection was associated with cystic fibrosis and M. xenopi infection was associated with male gender.

Conclusion: In our center mycobacterial infections were common, increasing, and of diverse species.  Clinical algorithms could predict TB vs. NTM.


Subject Category: C. Clinical studies of bacterial infections and antibacterials including sexually transmitted diseases and mycobacterial infections (surveys, epidemiology, and clinical trials)

Gowri Satyanarayana, MD, Infectious Disease, Beth Israel Deaconess, Boston, MA

Disclosures:

G. Satyanarayana, None

Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.