1072. Examination of Risk Factors Associated with Peripherally Inserted Central Catheter Infections in Patients with Hematologic Malignancies
Session: Poster Abstract Session: Infection in Immunocompromised Patients
Saturday, October 22, 2011
Room: Poster Hall B1
Background: 

Peripherally inserted central catheters (PICC) are becoming more widely used in immunocompromised cancer patients. Knowledge of risk factors associated with PICC infections, especially in patients with hematologic malignancies is very limited. Our objective is to identify risk factors associated with PICC infections in patients with hematologic malignancies.

Methods: 

We performed a retrospective case-control analysis of hospitalized patients with hematologic malignancies who had PICC in our cancer hospital from February 2008 through March 2010. We compared patients who developed PICC infection (cases) with those who did not (controls) matched for location and month of stay in the hospital during the specified time period. We examined age, tobacco and alcohol use, length and reason for PICC use, chemotherapy use, diagnosis of acute myeloid leukemia or other hematologic malignancies, presence Foley catheter and antibiotic use for these patients. Statistical analysis was performed by generating odds ratio (OR) by logistic regression for each characteristic.

Results: 

We studied 36 cases and 65 randomly selected controls. Clotting of PICC (OR: 1.82; 95% CI, 0.73 to 4.53), presence of a Foley catheter at the time of PICC placement (OR: 1.76; 95% CI, 0.69-4.48) and presence of PICC on admission (OR: 1.63; 95% CI, 0.61-4.42) had OR estimates greater than 1. Age (OR: 0.965, 95% CI, 0.94, 0.99), number of days with PICC in the hospital (OR: 1.04, 95% CI, 1.03, 1.08) and a diagnosis of acute myeloid leukemia (AML) (OR: 2.483, 95% CI, 1.063, 5.798) were significantly associated with PICC infection. Chemotherapy use was similar in both groups (36/36 cases vs. 60/65 controls).

Conclusion: 

The diagnosis of AML carries more risk for PICC infection compared to other hematologic malignancies. As the hospital days with PICC increase, the probability of getting infection increases, and that as the age increases, the probability of getting infection may decrease. The reason for reverse association of PICC infection with age in this study is unclear. Clotting of PICC, presence of Foley catheter at the time of PICC placement and presence of PICC on hospital admission may be associated with increased likelihood of infection.


Subject Category: C. Clinical studies of bacterial infections and antibacterials including sexually transmitted diseases and mycobacterial infections (surveys, epidemiology, and clinical trials)

Madhuri Sopirala, MD, MPH, Internal Medicine - Infectious Disease, Ohio State University Medical Center, Columbus, OH, Valerie Niedermier, Ohio State University College of Medicine, Columbus, OH and Xiaokui Mo, OSU Center for Biostatistics, Columbus, OH

Disclosures:

M. Sopirala, None

V. Niedermier, None

X. Mo, None

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