1211. HPV in Newborns
Session: Poster Abstract Session: Other Viral Infections in Children
Saturday, October 22, 2011
Room: Poster Hall B1
Handouts
  • HPV in newborns.pdf (113.7 kB)
  • Background: Maternal transmission of Human papillomavirus (HPV) has been described to occur mostly during vaginal delivery in women with condiloma. Other risk factors associated are premature rupture of membranes and cephalic presentation of the product. However, HPV transmission and prevalence in cesarean delivered neonates has been poorly described

    Methods: We investigated the prevalence of HPV in uterine cervix of pregnant women at the time of delivery, and in oral mucosa of their neonates, and studied the associated determinants. Molecular detection of HPV was performed using universal primers and nested PCR. This project was approved by the bioethical committee from the public Hospital in which the study was carried out; all women signed an informed consent to participate.

    Results: We performed HPV detection in 372 mother-newborn paired samples. Mothers’ age ranged between 16 to 41 years old (mean 23.4 years). Overal, HPV DNA was found in 8.9% (33) of the mothers’ cervical samples, and in 5.9% (22) of the newborns’ oral mucosa. Half of the HPV positive newborns were born by cesarean section.

    Vaginal delivery, premature rupture of membranes and cephalic presentation were not associated to HPV in the newborns. It was associated significantly to maternal age younger than 19 years old, OR= 3.32 (CI: 1.28 - 8.74) and to condiloma in the mother at the time of delivery OR=6.73 (CI: 1.29 - 31.37). Eleven out of 33 positive mothers presented condiloma; and 3 of their newborns were HPV positive (27%), all of them were born by cesarean delivery. The remaining 19 HPV positive neonates were born from positive mothers assumed to have a subclinical infection. A high percentage of these women (68.3%) had never participated in cervical cancer screening, and therefore, the presence of cervical lesions at that time was unknown.

    Conclusion: HPV in neonates was not related to the mode of delivery. Our results suggest the possible mother-newborn transmission of HPV in 66.6% of cases. In order to confirm this assumption, the complete genotyping of HPV positive samples in both mothers and newborns is needed. To our knowledge, this is the first study of HPV in neonates performed in Mexico. Longitudinal studies are required to investigate the clinical significance of these findings.


    Subject Category: P. Pediatric and perinatal infections

    Laura Conde-Ferraez, PhD1, Gladys Quintal1, Rosa Suarez1, Maribel Perez, MD2, Guadalupe Ayora-Talavera, PhD1 and Refugio Gonzalez-Losa, MD, PhD1, (1)Centro de Investigaciones Regionales, Universidad Autonoma de Yucatan, Merida, Mexico, (2)Hospital General Agustin O'Horan, Secretaria de Salud, Merida, Mexico

    Disclosures:

    L. Conde-Ferraez, None

    G. Quintal, None

    R. Suarez, None

    M. Perez, None

    G. Ayora-Talavera, None

    R. Gonzalez-Losa, None

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