1300. Molecular Epidemiology and Genetic Characterization of Enteroviruses Isolated in Korea, 2010
Session: Poster Abstract Session: Viral Epidemiology
Saturday, October 22, 2011
Room: Poster Hall B1
Background: The genus Enterovirus belongs to the Picornaviridae family and human enteroviruses (HEV)-A, B, C and –D. In the case of HEV, a total of 92 serotypes are currently recognized: HEV-A (17 serotypes), HEV-B (56 serotypes), HEV-C (16 serotypes, including the three polioviruses (PV) serptypes), and HEV-D (3 serotypes). Most of HEV infections are asymptomatic, but these viruses are implicated in a wide variety of clinical syndromes, ranging from minor febrile illness to severe, potentially fatal conditions such as neuromuscular complaints

Methods: In this study, we have analyzed the epidemic patterns of enteroviruses using molecular methods including RT-PCR and Real time RT-PCR.

Results: 

we have detected 1,370 EVs from 4,425 specimens during 2010 in Korea and most common clinical manifestation is HFMD/Herpangina (n=415) and followed by aseptic meningitis (n=357). Among detected samples, 316 EV serotypes were determined by viral VP1 semi-nested RT-PCR. Most strains belonged to HEV-A (n=220, 69.6%) followed by HEV-B (n=96, 30.4%). Predominant enterovirus type was EV71 (n=137, 43.4%) followed by CB1 (n=60, 19.0%) and CA2 (n=39, 12.7%).Eighty eight severe complication cases including 1 fatal case with HFMD by enterovirus 71 have been reported in Korea, 2010 and common genogroup was C4a.

Conclusion: The understanding of the recent epidemic pattern of circulating enteroviruses in Korea in this study will provide appropriate preparedness against HEV epidemics.


Subject Category: D. Diagnostic microbiology

Byunghak Kang, Seoyeon Hwang, Hyejin Kim, Doosung Cheon and Kisang Kim, KNIH, Chungcheongbukdo, South Korea

Disclosures:

B. Kang, None

S. Hwang, None

H. Kim, None

D. Cheon, None

K. Kim, None

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