1300. Molecular Epidemiology and Genetic Characterization of Enteroviruses Isolated in Korea, 2010
Session: Poster Abstract Session: Viral Epidemiology
Saturday, October 22, 2011
Room: Poster Hall B1
Background: The genus Enterovirus belongs to the Picornaviridae family and human enteroviruses (HEV)-A, B, C and –D. In the case of HEV, a total of 92 serotypes are currently recognized: HEV-A (17 serotypes), HEV-B (56 serotypes), HEV-C (16 serotypes, including the three polioviruses (PV) serptypes), and HEV-D (3 serotypes). Most of HEV infections are asymptomatic, but these viruses are implicated in a wide variety of clinical syndromes, ranging from minor febrile illness to severe, potentially fatal conditions such as neuromuscular complaints

Methods: In this study, we have analyzed the epidemic patterns of enteroviruses using molecular methods including RT-PCR and Real time RT-PCR.


we have detected 1,370 EVs from 4,425 specimens during 2010 in Korea and most common clinical manifestation is HFMD/Herpangina (n=415) and followed by aseptic meningitis (n=357). Among detected samples, 316 EV serotypes were determined by viral VP1 semi-nested RT-PCR. Most strains belonged to HEV-A (n=220, 69.6%) followed by HEV-B (n=96, 30.4%). Predominant enterovirus type was EV71 (n=137, 43.4%) followed by CB1 (n=60, 19.0%) and CA2 (n=39, 12.7%).Eighty eight severe complication cases including 1 fatal case with HFMD by enterovirus 71 have been reported in Korea, 2010 and common genogroup was C4a.

Conclusion: The understanding of the recent epidemic pattern of circulating enteroviruses in Korea in this study will provide appropriate preparedness against HEV epidemics.

Subject Category: D. Diagnostic microbiology

Byunghak Kang, Seoyeon Hwang, Hyejin Kim, Doosung Cheon and Kisang Kim, KNIH, Chungcheongbukdo, South Korea


B. Kang, None

S. Hwang, None

H. Kim, None

D. Cheon, None

K. Kim, None

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