1132. A different mix of circulating respiratory viruses during the pandemic 2009-2010 & the post pandemic 2010-2011 influenza season
Session: Poster Abstract Session: Influenza and H1N1 Diagnosis, Epidemiology, and Viral Outcome
Saturday, October 22, 2011
Room: Poster Hall B1
Background: We evaluated the use of a clinical array method in diagnosing respiratory tract infections in a tertiary care hospital ER, during the pandemic (2009-2010) & post pandemic (2010-2011) influenza seasons in Greece.

Methods: Consecutive patients with symptoms of respiratory tract infection visiting the ER of a tertiary care hospital were evaluated during the 2 consecutive winter seasons of 2009-10 & 2010-11. Clinical samples were collected into ThinPrep CytoLyt® solution. CLART® PneumoVir kit, (Genomica, Spain) was used for viral detection of all known respiratory viruses.

Results: 204 consecutive patients (median age 22 yrs, range: 18d-93yrs, 51.5% male) have been examined [106 (52%) from the 2010-11 season]. The most prevalent repsiratory viruses identified during the 2009-10 & 2010-11 season included: i)Respiratory Syncytial Virus (RSV): prevalence of 45.9% (95%CI: 35.9%-56.3%) & 70.8% (95%CI: 61%-78.9%) respectively & ii) Influenza virus A(H1N1) 2009 (>99% of prevalent influenza cases in Greece during 2009-10 & 2010-11): 48% (95%CI: 37.8%-51.2%) & 23.6% (95%CI: 22.8%-44.7%). Other viruses identified were: Coronavirus 1%, Rhinovirus 1% (2009-10) &  human Metapneumovirus 7.5% (95%CI: 3.6-14.8%), Rhinovirus 5.7% (95% CI: 2.3-12.4%), Adenovirus 2.8% (95%CI: 0.7%-8.6%) & Bocavirus 0.9% during 2010-11. Mixed infections were identified in 27.6% (95%CI: 19.2-37.7) of patients during 2009-10 & in 29.2% (95% CI: 21-39%) during 2010-11 (most frequently influenza A (H1N1) & an RSV type). Rates of RSV were higher in children compared to adults (p = 0.02) while rates of influenza increased with advancing age (p=0.004).

Conclusion: Higher rates of RSV were noted during 2010-11 influenza season. HMPV & rhinovirus infection where additionally observed. In addition, in the study population, high rates of mixed infections with RSV & A (H1N1)2009 viruses were observed for both seasons in a highly unvaccinated population.


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Zacharoula Oikonomopoulou, MD1, Konstantinos Leventakos, MD2, Aikaterini Chranioti, MD PhD3, Maria Alepaki4, Konstantinos Douros, MD5, Angelos Hatzakis, MD PhD6, Dimitrios Paraskevis, MD PhD6, Aikaterini Chaida6, Petros Karakitsos, MD PhD3, George Petrikkos, MD2, Poluxeni Nikolaidou-Karpathiou, MD PhD7 and Sotirios Tsiodras, MD PhD2, (1)Attikon University General Hospital, Univ of Athens Med Sch, Haidari, Greece, (2)4th Internal Medicine Department, Attikon University General Hospital, Univ of Athens Med Sch, Haidari, Greece, (3)Department of cytopathology, Attikon University General Hospital, Univ of Athens Med Sch, Haidari, Greece, (4)Department of cytopathology, Attikon University General Hospital, Haidari, Greece, (5)3rd Pediatrics Department, Attikon University General Hospital, Haidari, Greece, (6)Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece, (7)3rd Pediatrics Department, Attikon University General Hospital, Univ of Athens Med Sch, Haidari, Greece

Disclosures:

Z. Oikonomopoulou, None

K. Leventakos, None

A. Chranioti, None

M. Alepaki, None

K. Douros, None

A. Hatzakis, None

D. Paraskevis, None

A. Chaida, None

P. Karakitsos, None

G. Petrikkos, None

P. Nikolaidou-Karpathiou, None

S. Tsiodras, None

Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.