987. Impact of Disease Burden of Meningitis. Why Vaccinate?
Session: Poster Abstract Session: Clinical Studies of Bacterial Infection
Saturday, October 22, 2011
Room: Poster Hall B1
Background: The aim of this study was to quantify Disability Adjusted Life Years (DALY´s) associated with bacterial meningitis in Argentina and other countries in the region (Chile, Brazil and Mexico) for the year 2008.

Methods: We analyzed the disease burden of bacterial meningitis (ICD-10: G00-03) for 2008 and we estimated DALY´s (Years of Life Lost due to premature mortality -YLL´s- plus Years Lived with Disability -YLD´s-).We analyzed mortality data from the Bureau of Vital Statistics of the Ministry of Health of Argentina and neighboring countries.  We estimated YLL´s for each stratum using the criteria standard life expectancy, the discount rate of 3% and non-uniform age weights. To calculate YLD´s, the methodology was based on YLD/YLL reasons already known for low-and middle-income countries of the American region as stated by the Global Burden of Disease 2004. The DALY´s behavior in different countries was estimated through the age-standardized rates using the world standard population as defined by WHO for the period 2000-2025.

Results: For 2008, 347 meningitis deaths were reported in Argentina, 85 in Chile, 1158 in Brazil and 363 deaths in Mexico.The YLD / YLL rater was for each country: 1625/6632, 428/1623, 7159/29029 and 2130/8420, respectively. In all countries, this ratio of YLD / YLL was very low, between 0.2 and 0.3, indicating that the weight of YLL´s was higher than in the years lived with disability. The meningitis DALY´s were 8256 for Argentina, 2051 for Chile, 36187 for Brazil and 10551 for Mexico. The greatest weight was observed in children under 4 years (33.4% 30.9%, 35.8%, 26.05%, respectively) and between 15 to 59 years (45.8%, 38.5 %, 45.1%, 55.5%, respectively). The countries with the highest burden of meningococcal disease were Argentina and Brazil (21.1 and 19.2 DALYs perdidos/100.000 hab., respectively). Argentina has a higher 64% higher than Chile (21.1 vs. 12.9) and 110% higher than Mexico (21.1 vs. 10.0).

Conclusion: The analysis of the burden of disease are useful to inform health policy, directing them toward interventions cost-effective vaccination against prevalent microorganisms.


Subject Category: C. Clinical studies of bacterial infections and antibacterials including sexually transmitted diseases and mycobacterial infections (surveys, epidemiology, and clinical trials)

Teresa Zitto1, Horacio Lopez1, Daniel Grilli1 and Gabriela Vidal2, (1)Centro de Infectología, Buenos Aires, Argentina, (2)Novartis Vaccines, Novartis Argentina, Buenos Aires, Argentina

Disclosures:

T. Zitto, None

H. Lopez, None

D. Grilli, None

G. Vidal, Novartis Argentina: Employee, Salary

Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.