613. Cluster of Extragenital Mycoplasma hominis Infections in Intensive Care Unit Patients
Session: Poster Abstract Session: Outbreak Investigation
Friday, October 21, 2011
Room: Poster Hall B1
Handouts
  • MHominis.pdf (799.2 kB)
  • Background: Mycoplasma hominis is a genitourinary (GU) pathogen, although extragenital colonization and infection are reported. While M. hominis can be aerosolized or transmitted sexually, outbreaks are rare because it is susceptible to drying and ultraviolet light. We report the first cluster of extragenital M. hominis infections in immunocompetent adult patients.

    Methods: In Jan 2011, the hospital epidemiologist was alerted to M. hominis isolates from two intensive care unit (ICU) patients. The organisms grew on blood agar incubated at 37° C for 72 hours; no organisms were seen on Gram’s stain. Isolates were sent to a reference laboratory to confirm speciation and homology via sequencing. Medical charts were reviewed to collect the patients’ hospital locations, operating rooms (OR), common medical staff members, and treatment courses.

    Results: Patient 1 was a 40 y.o. male admitted with a closed head injury and facial fractures after a motor vehicle accident. A M. hominis intracranial abscess was discovered five days after evacuation of a hematoma. He underwent three drainage procedures for this infection; M. hominis was isolated from the first and third surgeries. He received doxycycline and improved. Patient 2 was an 18 y.o. woman admitted for an impalement injury resulting in GU disruption, small bowel injury, and diaphragmatic rupture. M. hominis grew from pleural fluid twice and from pelvic fluid once. She was given levofloxacin for ten days and recovered.

    The patients were cared for in the same ICU concurrently, although their rooms were not adjoining. There were two OR dates in common, but the patients were operated on in different ORs. Twenty staff members were common to both patients’ charts; 12 were considered close contacts. Gene sequencing revealed identical isolates, although these isolates also matched M. hominis strains from different areas of the country.

    Conclusion: M. hominis can be a nosocomial pathogen in immunocompetent trauma patients. We suspect this cluster was due to contaminated hands or aerosolized droplets from a colonized staff member. Gene sequencing may be inadequate to determine if horizontal transmission occurs between patients.


    Subject Category: N. Hospital-acquired and surgical infections, infection control, and health outcomes including general public health and health services research

    Heather Young, MD, Infectious Diseases, Denver Health Medical Center, Denver, CO, Michael Wilson, MD, Pathology, Denver Health Medical Center, Denver, CO, Andres Henao-Martinez, MD, Infectious Diseases, University of Colorado Hospital, Aurora, CO and Connie Price, MD, Denver Health Medical Center, Denver, CO

    Disclosures:

    H. Young, None

    M. Wilson, None

    A. Henao-Martinez, None

    C. Price, None

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