1202. Pertussis Infection in Hospitalized Infants in Samsun, Turkey
Session: Poster Abstract Session: Other Bacterial Infections in Children
Saturday, October 22, 2011
Room: Poster Hall B1
Background: 

To investigate the clinical features and outcome of infants  hospitalized with pertussis.

Methods: 

We reviewed the medical records of infants hospitalized with pertussis infection in our hospital between January 2008-December 2010. WHO case definition for pertussis was used in the diagnosis.

Results: 

Twenty-one infants with pertussis (17 clinically diagnosed, and 4 confirmed cases) were included in the study. In three cases, Bortedella pertussis (B. pertussis) was isolated from cultures of nasopharyngeal swaps and in one case from culture of  deep tracheal aspirate sample. Sixteen cases were diagnosed in the year of 2010, and 11 of the cases presented in the summer months. Eleven (52%) of the cases were exposed to a family member who was coughing. Mean (± SD) age of the cases was 2.19 ± 0.77 months and 17 (80.9%) of the cases were younger than 3 months of age. Sixteen cases had not been vaccinated yet, and 5 cases had received only one dose. All but one of the cases presented with paroxymal cough. The other most frequent symptoms were cyanosis (19 cases, 90.5%), vomiting (5 cases, 23.8%), respiratory distress (2 cases, 9.5%), and fever (2 cases, 9.5%). Pneumonia developed in 4 cases. Mean (± SD) white blood cell count (WBC) was 18895 ± 17293/mm3 (min: 14600/mm3, max: 89600/mm3), and lymphocyte count was 11499 ± 6779/mm3 (min: 5300/mm3, max: 34100/mm3). Mean (± SD) duration of hospitalization was 7.3 ± 3.2 days. Two cases needed ventilatory support in the intensive care unit. All but one cases were recovered. One case, aged 38 days, who was entubated due to respiratory failure at admission, developed multi organ failure and he died on the 3th day of hospitalization. WBC count of this patient was 89600/mm3, and lymphocyte count was  34100/mm3. B. pertussis was isolated from culture of deep tracheal aspirate sample of the patient.  

Conclusion: 

Pertussis infection in young infants is not a benign disease and can result in hospitalization and even death. Adolescent and adult booster immunisation to reduce pertussis transmission to susceptible infants too young to be immunized should be considered in our country.


Subject Category: P. Pediatric and perinatal infections

Gülnar Sensoy, Professor1, Nursen Belet, Associate, Professor1, Muhammet Akgun1, Nazik Asilioglu, Assistant, Professor2 and Ayse Ayzit Kilinc3, (1)Pediatric Infectious Diseases, Ondokuz Mayis University, Samsun, Turkey, (2)Intensive care unit, Ondokuz Mayis University, Samsun, Turkey, (3)Pediatrics, Ondokuz Mayis University, Samsun, Turkey

Disclosures:

G. Sensoy, None

N. Belet, None

M. Akgun, None

N. Asilioglu, None

A. A. Kilinc, None

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