1069. Non-gastrointestinal Aeromonas Hydrophila Infections in Cancer Patients
Session: Poster Abstract Session: Infection in Immunocompromised Patients
Saturday, October 22, 2011
Room: Poster Hall B1
Background Immunocompetent individuals can become infected with Aeromonas hydrophila through cuts and abrasions of the skin or by non-fatal drowning incidents in fresh water. Immunodeficient patients often present with more severe infections. In such populations, reported cases have involved enteric infections, bacteremia, meningitis, peritonitis, cholecystitis and necrotizing fasciitis.  Lacerations or skin abrasions sustained in bodies of fresh water may result in cellulitis.

Methods:Records of the H. Lee Moffitt Cancer Center and Research Institute were reviewed over a period of 23 years, from 1/01/1985 to 6/30/2008.

Results: Aeromonas hydrophila was identified from various body fluids in 24 symptomatic cancer patients. 16  were from stool isolates and were excluded from analysis.   8 symptomatic patients had isolates from non-gastrointestinal sites including 6 with positive blood cultures and 2 from abscesses.  2 of the 6 patients with positive blood cultures were neutropenic at the time of diagnosis. A. hydrophila causing 2 cases of soft tissue infections was isolated from drainage of extremity wounds following trauma. Both were males with a history of hematologic malignancies with profound neutropenia.

Conclusion: 

Aeromonas spp. are among the most aggressive pathogens in adults with hematological malignancies or solid tumors, presenting as sepsis syndrome or pneumonia.

Hematological malignancies could be a predisposing condition of bacteremic cases and soft tissue infections. 

  The majority of isolates of Aeromonas from infected patients are A. hydrophila.  Ubiquitous in the environmental samples such as creek water, it is one of the major culprits of soft-tissue infection following trauma in fresh water.  Except for the gastrointestinal tract, wounds are the most common site for Aeromonas growth. 

 Most of the patients with soft-tissue involvement acquired the infection in the community and presented with local abscess and fever. 

Aeromonas infections can be treated with broad spectrum beta-lactam antibiotics including third generation cephalosporins, imipenem, aztreonam, or fluoroquinolones without additional aminoglycoside therapy.


Subject Category: C. Clinical studies of bacterial infections and antibacterials including sexually transmitted diseases and mycobacterial infections (surveys, epidemiology, and clinical trials)

Luis Rosas, MD1, Beata Casanas, DO2, Amit Pathak3, Veronica Tucci4, Austin Payor3, Albert Vincent, PhD5 and John Greene, MD4,5, (1)Infectious DIsease, University Of South Florida, Tampa, FL, (2)Moffitt Cancer Center (MCC), Tampa, FL, (3)Moffitt Cancer Center, Tampa, FL, (4)University of South Florida, Tampa, FL, (5)H. Lee Moffitt Cancer Center, Tampa, FL

Disclosures:

L. Rosas, None

B. Casanas, None

A. Pathak, None

V. Tucci, None

A. Payor, None

A. Vincent, None

J. Greene, None

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