1213. Congenital Cytomegalovirus-related Hospitalizations in Infants in the United States, 1997-2006
Session: Poster Abstract Session: Pediatric CMV and Other Herpes Infections
Saturday, October 22, 2011
Room: Poster Hall B1
Background: An estimated 30,000–40,000 infants are born with congenital cytomegalovirus (cCMV) infection annually in the United States, with 3800–5100 (13%) symptomatic at birth. The proportion of infants with cCMV infection who require hospitalization is unknown but important for understanding the impact that vaccination or treatment could have in reducing the burden and costs of cCMV disease.

Methods: Data from the Healthcare Cost and Utilization Project KIDS’ inpatient database were analyzed to determine numbers and rates of cCMV-related hospitalizations among infants (<1 year of age) for 1997, 2000, 2003 and 2006, the years the survey was conducted. A cCMV-related hospitalization was defined as one with ICD-9 codes 078.5 (CMV) or 771.1 (cCMV) in any position for an infant with no HIV or transplant-related codes. ICD-9 codes were also used to identify conditions commonly associated with cCMV infections. Results were extrapolated to represent national estimates.

Results: An estimated 5405 cCMV-related hospitalizations occurred among infants in the United States during the four study years; 1781 (33%) occurred among infants <1 month of age. The average annual cCMV-related hospitalization rate among infants was 34.2/100,000, with no statistically significant differences over the four study years. Rates were higher in non-Hispanic blacks (41.2/100,000) than whites (19.3/100,000) or Hispanics (29.3/100,000) (p<0.01). The most common, potentially CMV-related conditions were respiratory distress (37%), low birth weight (27%), thrombocytopenia (25%), and jaundice (20%). A total of 183 (3%) cCMV-related hospitalizations (average 46/year) ended in death.

Conclusion: Although these data represent hospitalizations and not individual cases of cCMV, the number of hospitalizations detected approximates the expected number of infants with symptomatic cCMV disease at birth. cCMV-related hospitalization rates varied by race, consistent with previously reported incidence of cCMV infection. Although hospital discharge data may not be ideal for capturing all CMV-related conditions, these data may be useful for tracking trends in severe, symptomatic cCMV infection to monitor impact of strategies to prevent or treat cCMV infection.

Subject Category: P. Pediatric and perinatal infections

Adriana S Lopez, MHS, CDC, Atlanta, GA; Centers for Disease Control and Prevention, Atlanta, GA and Stephanie R. Bialek, MD, MPH, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA


A. S. Lopez, None

S. R. Bialek, None

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