933. Rhinovirus Strains Circulating in Central and South America
Session: Poster Abstract Session: Biomarkers and Risk Factors for Viral Infections
Saturday, October 22, 2011
Room: Poster Hall B1
Background:
Human rhinoviruses (HRVs) are a highly prevalent cause of respiratory disease. These viruses primarily affect children, but they have also been detected in populations such as young military recruits. HRVs are one of nine genera belonging to the Picornaviridae family with high similarity to enteroviruses. There are more than 100 different serotypes that have been taxonomically grouped into 2 species: HRV-A and HRV-B. Recently, a new species named HRV-C was identified in patients with acute lower respiratory tract infections (LRTIs) in the United States, Australia, and Hong Kong. Since its detection, HRV-C has been reported to be an important etiological factor in children, causing up to 5% of LRTIs among inpatients and accounting for 73% of LRTI cases in children in Germany. Other studies have shown that HRVs possess great genetic diversity by recombination not only among different HRV species, but also with enteroviruses. Although some information exists about HRVs in Amazon tribes, very little other data is known about HRV and its respective species in Latin America.
In this study, we investigated the current circulation of HRVs in young adults and children from nine countries in Latin America with emphasis on the HRV-C species of HRVs.

Methods:
We collected nasopharyngeal throat swab specimens at hospitals throughout Central and South America from patients who presented with a febrile, respiratory syndrome. Virus detection was carried out by RT-PCR followed by sequencing for genotype determination.

Results:
One thousand seven hundred and eight-three samples were analyzed, 288 (16.2%) samples were positive for HRV by PCR, and 54 of them were serotype HRV-C (18.8% of positive samples). Phylogenetic trees show great variety of strains in circulation and a clear predominance of the HRV-A strains. We detected 30 co-infections (10.4%) with influenza virus A and B, adenovirus, enterovirus, human metapneumovirus, and parainfluenza 1 and 3.

Conclusion:
HRVs, including HRV-C, are frequent etiologic agents of respiratory disease in Latin America.


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Josefina Garcia, PhD1, Merly Sovero2, Victoria Espejo2, Manuel Villaran2, Jorge Gomez, MD3, Felix Sanchez4, Guillermo Comach, PhD5, Ana Arango6, Nicolas Aguayo7, Wilson Chicaiza8, Mirna Jimenez9, Alberto Laguna-Torres2, Tadeusz J. Kochel, PhD10 and Eric S. Halsey, MD2, (1)US Naval Medical Research Unit-6, Washington DC, DC, (2)NAMRU-6, Lima, Peru, (3)Dirección General de Epidemiologia, Ministerio de Salud, Lima, Peru, (4)Hospital Infantil Manuel de Jesus Rivera, Managua, Nicaragua, (5)Laboratorio Regional de Diagnostico e Investigacion del Dengue y otras, Maracay, Venezuela, (6)Universidad de Antioquia, Medellín, Colombia, (7)ONG Rayos de Sol, Asuncion, Paraguay, (8)Hospital Vozandes, Quito, Ecuador, (9)Hospital Nacional de Metapan, Metapan, El Salvador, (10)Viral and Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, MD

Disclosures:

J. Garcia, None

M. Sovero, None

V. Espejo, None

M. Villaran, None

J. Gomez, None

F. Sanchez, None

G. Comach, None

A. Arango, None

N. Aguayo, None

W. Chicaiza, None

M. Jimenez, None

A. Laguna-Torres, None

T. J. Kochel, None

E. S. Halsey, None

Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.