541. Sustained High Influenza Vaccination Rates and Decreased Safety Concerns among Pregnant Women During the 2010–2011 Influenza Season
Session: Poster Abstract Session: Influenza Vaccines
Friday, October 21, 2011
Room: Poster Hall B1
Background: Historically pregnant women have had the lowest uptake of influenza vaccine among all priority groups.  Whether significantly increased vaccination rates achieved among pregnant women during the 2009 H1N1 pandemic will be sustainable is unknown.  We surveyed postpartum women during both the 2009-10 and 2010-11 influenza seasons to determine vaccine uptake and reasons for lack of vaccination.

Methods: We administered brief surveys on postpartum day 1 or 2 to women delivering at our 900-bed community-based academic medical center during Feb 1-Apr 15, 2010, and during Feb 1–Mar 8, 2011. The surveys ascertained maternal characteristics, history of prior/current influenza vaccination, and reasons for lack of vaccination.  Exclusion criteria included age <18 years, non-live birth, and transfer from another facility.  We used logistic regression to determine factors that were associated with vaccination during pregnancy.

Results: During the 2009-10 season, 191 of 307 (62%) postpartum women surveyed had received H1N1 vaccine and 186 (61%) received seasonal influenza vaccine during pregnancy.  In 2010-11, 165 (55%) of 300 women surveyed had received influenza vaccination.  In multivariable analysis, predictors of influenza vaccination in 2010-11 included having private insurance (OR 2.6, 95% CI 1.2 – 6.1), having been vaccinated during a prior pregnancy (OR 6.4, 95% CI 2.5 – 16.5), having received 2009 H1N1 vaccine (OR 3.0, 95% CI 1.4 – 6.5), and doctor recommendation of influenza vaccine (OR 18.4, 95% CI 7.5 – 45.0).  While concern about vaccine safety was cited by a majority (66%) of those who had declined vaccination during 2009-10, only 28 (26%) of 109 women who declined vaccine in 2010-11 cited safety concerns.  Not usually getting a flu shot (62%), lack of perceived risk of getting influenza (50%), and lack of perceived risk of severe illness from influenza (35%) were the most commonly cited reasons for refusal.

Conclusion:  Despite significantly less public health and media focus on influenza during the 2010–11 season, pregnant women at our institution continued to accept flu vaccine at substantially higher rates than has been historically reported.  Concern about vaccine safety, the primary barrier during 2009–10, was a much less significant concern.

Subject Category: I. Adult and Pediatric Vaccines

Marci Drees, MD, MS1,2, Barbara Tambourelli, RN1, Amy Denstman, MBA1, Robie Zent, RN1, Patty McGraw, RN, MS1 and Deborah Ehrenthal, MD1,2, (1)Christiana Care Health System, Newark, DE, (2)Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA


M. Drees, None

B. Tambourelli, None

A. Denstman, None

R. Zent, None

P. McGraw, None

D. Ehrenthal, None

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