336. Herpes Zoster among Partially Vaccinated Pediatric Population in Central Israel
Session: Poster Abstract Session: Challenges in Vaccinology and Vaccine Exploration
Friday, October 21, 2011
Room: Poster Hall B1
Handouts
  • zoster IDSA poster 2.PNG (195.5 kB)
  • Background:

    The objectives of this study were to estimate the current rate of Pediatric HZ (Herpes Zoster), to describe the clinical and epidemiological characterization of the ambulatory cases, and to identify risk factors for its appearance. The study was performed during an era of partial vaccination with VZV (Varicella Zoster Virus) vaccine in Israel.

    Methods: 

    A retrospective data collection regarding children aged 0-18 years, diagnosed with HZ during 2006 – 2008. Data were retrieved from a computerized database containing medical information of a population of about 114,000 children aged 0-18 years, residing in Hasharon County, and insured by “Maccabi Health Services”.

    Records were reviewed by Pediatric Infectious Diseases expert in order to confirm the diagnosis. Epidemiological and clinical characteristics were recorded as well as identification of risk factors. 

    Telephone interviews were done with some of the parents to get further clinical details.

    Results: 

    Out of 519 medical records reviewed, 383 cases were approved for analysis and 77 interviews were done.  Incidence of HZ was 158/100,000 person-life-years; peak incidence was detected in children aged 10-11 years (279/100,000 person-life-years). Pain and fever accompanied 52% and 13% of episodes respectively. Higher risk for HZ was found in children who had varicella during their 1st year of life (RR & 95% CI: 13.7 [9.9-18.4], p<0.001), and in children who had varicella during the second year of life; RR=2.8 (2.07–3.67); p<0.001).

    Varicella vaccination rate among the Pediatric population in Hasharon County was 28%. Vaccination was found to be protective against HZ (RR=0.38 (0.27-0.52) p<0.001).

    Conclusion:

    We found that childhood HZ is more frequent than previously reported. Our data revealed a unique epidemiology for childhood HZ in a population with partial coverage with varicella vaccine. These results have verified the protective effect of varicella vaccine on the incidence of zoster and demonstrated that children who were younger than 2 years of age had increased risk for HZ during childhood.


    Subject Category: I. Adult and Pediatric Vaccines

    Michal Stein, MD1, Rinat Cohen, MD2, Michal Bromberg, MD3, Diana Tasher, MD4, Tamar Shohat, MD5 and Eli Somekh, MD4, (1)Pediatric Infectious Diseases Unit, Wolfson Medical Center, Holon, Israel, (2)Maccabi Health services, Hasharon County, Ramat-Hasharon , Israel, (3)Israel Center for Disease Control, Tel-Hashomer, Israel, (4)Wolfson Medical Center, Holon, Israel, (5)ICDC, Tel Hashomer, Israel

    Disclosures:

    M. Stein, None

    R. Cohen, None

    M. Bromberg, None

    D. Tasher, None

    T. Shohat, None

    E. Somekh, None

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