881. Helicobacter pylori infection is associated with increased rate of diabetes
Session: Oral Abstract Session: Microbiome and Susceptibility to Infection
Saturday, October 22, 2011: 11:30 AM
Room: 156ABC
Background: Chronic infections could be contributing to the socioeconomic gradient in chronic diseases.  While chronic infections have been associated with increased levels of inflammatory cytokines and cardiovascular disease, there is limited evidence on how infections affect risk of diabetes.

Methods: We examined the association between serological evidence of chronic viral and bacterial infections and incident diabetes in a prospective cohort of Latino elderly.  We analyzed data on 790 individuals aged >60 years and diabetes-free in 1998-1999, whose blood were tested for antibodies to herpes simplex virus 1, varicella virus, cytomegalovirus, helicobacter pylori and toxoplasma gondii and were followed until June, 2008.  We employed Cox proportional-hazards regression to estimate the relative incidence rate of diabetes by serostatus with adjustment for age, sex, education, cardiovascular disease, smoking, and cholesterol levels.

Results: Individuals seropositive for herpes simplex virus 1, varicella virus, cytomegalovirus and toxoplasma gondii did not show an increased incidence rate of diabetes, while those who were seropositive for H. pylori at enrollment were 2.8 times more likely at any given time to develop diabetes than seronegative individuals (hazard ratio = 2.80, 95%CI: 1.15-6.85).  Controlling for insulin resistance, c-reactive protein and interleukin-6 did not attenuate the effect of H. pylori infection.

Conclusion: We demonstrated for the first time that H. pylori infection leads to increased rate of incident diabetes in prospective cohort study.  Our findings implicate a potential role for antibiotic and gastrointestinal treatment in prevention of diabetes.

Subject Category: C. Clinical studies of bacterial infections and antibacterials including sexually transmitted diseases and mycobacterial infections (surveys, epidemiology, and clinical trials)

Christie Jeon, ScD1, Mary Haan, DrPH, MPH2, Caroline Cheng, MS3, Erin Clayton, MS3, Elizabeth Mayeda, MS2 and Allison Aiello, PhD, MS3, (1)ICAP, Mailman School of Public Health, Columbia U, New York, NY, (2)Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, (3)University of Michigan School of Public Health, Department of Epidemiology, Ann Arbor, MI


C. Jeon, None

M. Haan, None

C. Cheng, None

E. Clayton, None

E. Mayeda, None

A. Aiello, None

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