1287. Trends in Acute Care Hospitalizations for Male HPV Associated Genital Malignancies in California: 1990-2007
Session: Poster Abstract Session: Viral Epidemiology
Saturday, October 22, 2011
Room: Poster Hall B1
Background:More than 90% of anal, and 50% of penile cancers are attributable to HPV. Moreover, elevated anal cancer incidence is well documented in select California populations. Evaluating trends in male HPV associated genital malignancies may focus preventative efforts. 

Methods:We identified men with acute care hospital (ACH) discharge diagnoses of penile and/or anal cancer between 1990-2007 from the California OSHPD database. Additional hospitalization data including age, insurance type, length of hospital stay and HIV infection were also collected. Trends in male HPV associated genital malignancies by race/ethnicity were reviewed. Data were analyzed with R-2.11.1 and Joinpoint Regression Program-3.4. 

Results:We identified 5,218 men with penile, and/or anal cancer ACH of which 66% were White, 20% Hispanic, 9%Black, 3%Asian, and 2% other. Forty percent had ACH for penile cancer, 49% for anal cancer, and 11% both anal cancer and HIV. Less than 30% of men in our cohort had Private Insurance (PI). From 1990-2007, rates of penile cancer ACH increased slightly and were significantly different between White and Hispanic males (p=0.008). Hispanics had higher rates of penile cancer ACH than Asians (p<0.001). Rates of anal cancer ACH were higher for White men compared to Hispanics (p< 0.001) but not Black men (p=0.26).  The difference between anal cancer ACH rates for White and Hispanic men have significantly changed over time, (APC =2.53, APC=8.26 for White and Hispanic men respectively; p <0.001).  The difference between rates for White and Black men have not changed significantly (p =0.20). 

Conclusion:Rates of penile cancer ACH for all racial/ethnic groups were consistent with national trends. However, rates of anal cancer ACH were similar between Black and White men. This differs from California and national data demonstrating higher rates of anal cancer diagnosis among Black men compared to white men. Our results may indicate that Black men were less likely to be hospitalized for anal cancer. Few patients in our cohort had PI. This may reflect a lack of access to insurance among some populations. Equal access to insurance and preventative care in at-risk communities may lessen ACH for HPV associated genital malignancies in men.


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Candice J. McNeil, MD, MPH, Infectious Diseases, Stanford University, Stanford, CA, Andrew Anglemyer, PhD, Pediatrics, Division of Infectious Diseases, Stanford University, Stanford, CA and Yvonne Maldonado, MD, Pediatric Infectious Diseases, Stanford University School of Medicine, Stanford, CA

Disclosures:

C. J. McNeil, None

A. Anglemyer, None

Y. Maldonado, None

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