633. Pediatricians’ Preferences for Infant Meningococcal Vaccination
Session: Poster Abstract Session: Pediatric Vaccines
Friday, October 21, 2011
Room: Poster Hall B1
Background: Value-for-money evaluations of vaccines are often sensitive to disease incidence; with higher incidences resulting in more favorable results.  However, health-care providers and the public may also be concerned about other disease characteristics, including the distribution of risks among sub-populations and the severity of the disease including long-term complications.   Meningococcal disease is a rare infection, but it can cause death or long-term disabilities such as neurological impairment, amputation, and hearing loss. This study aims to estimate pediatricians’ preferences for (1) infant meningococcal vaccines and vaccine features and (2) preventing diseases with varying levels of incidence and severity.

Methods: Pediatricians completed an online survey with a series of choice-format conjoint tasks. The trade-off tasks required subjects to choose between two hypothetical vaccine options with differing levels of vaccine attributes, including the number of cases of disease, death, and disability prevented, the age at which protection against the disease begins, the number of additional injections required, the number of additional office visits required to administer the vaccine, and the personal cost to parents.  Vaccine preference parameters were estimated using a mixed-logit choice model controlling for physician-specific characteristics.

Results: Among the 200 pediatricians who completed the survey, the number of cases of meningococcal disease prevented, the age at which protection begins, and the number of additional office visits required to administer the vaccine were the most important factors in vaccine preferences. The least important factor in vaccine preferences was the number of injections added to the immunization schedule. When choosing among vaccines for different diseases, incidence and the severity of outcomes have similar weight in physicians’ vaccine preferences. 

Conclusion: Physicians place a relatively high value on the prevention of rare diseases with high risks of death and serious long-term disability. These results suggest that conventional value-for-money evaluations do not accurately account for the value health-care providers place on preventing meningococcal infections.


Subject Category: I. Adult and Pediatric Vaccines

Christine Poulos, Ph.D.1, Reed Johnson, Ph.D.1, Girishanthy Krishnarajah2, Andrea Anonychuk3 and Derek Misurski, PhD4, (1)Research Triangle Institute, Durham, NC, (2)GlaxoSmithKline, Philadelphia, PA, (3)GlaxoSmithKline Biologicals, Rixensart, Belgium, (4)Global Health Outcomes, Vaccines, GlaxoSmithKline, Philadelphia, PA

Disclosures:

C. Poulos, None

R. Johnson, None

G. Krishnarajah, None

A. Anonychuk, None

D. Misurski, None

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