399. Increasing Trend in Hospitalizations for Pasteurellosis, United States, 2000-2008
Session: Poster Abstract Session: Gram Negative Infection - Epidemiology and Prevention
Friday, October 21, 2011
Room: Poster Hall B1
Background: Pasteurella multocida are common oral and gastrointestinal flora in many animals. Human infection usually occurs secondary to dog or cat bites. Soft tissue infections are most common. Regional adenopathy, subcutaneous abscesses, and tenosynovitis are frequent complications. Septic arthritis, osteomyelitis, sepsis, meningitis, and pneumonia are infrequent manifestations. Pet ownership has increased among U.S. households in recent decades. The population also is aging. Little is known about national epidemiology of Pasteurella infections.

Methods: We used the Nationwide Inpatient Sample database from the Healthcare Cost and Utilization Project to evaluate frequency of hospitalizations with associated International Classification of Disease, 9th revision (ICD-9) code 027.2, pasteurellosis, from 2000-2008.  Data were stratified by age group and region.  Population estimates were determined using census data for each year.

Results: Total U.S. hospitalizations and hospitalization incidence with associated ICD-9 codes for pasteurellosis nearly doubled from 1,392 events/0.49 per 100,000 in 2000 to 2,495 events/0.82 per 100,000 in 2008. Hospitalization incidences increased among each age group (0-17 y, 18-44 y, 45-64 y, 65-84 y, and 85+ y). Rates are highest in older age groups. In 2008 rates/100,000 were 0.20 in 0-17 y, 0.40 in 18-44, 1.22 in 45-64, 2.35 in 65-84, and 3.48 in 85+.  Rates varied slightly by region and increased the most in the Northeast, from 0.38 in 2000 to 0.99 in 2008. Rates in the South increased from 0.47 to 0.71.

Conclusion: Hospitalizations associated with pasteurellosis diagnoses increased in the U.S. from 2000 to 2008. Increases occurred in all age groups and regions. Hospitalization occurred more frequently among older age groups, which could reflect greater incidence of infection, possibly due to greater exposure to cats as pets, or higher rates of hospitalization among pasteurellosis cases among older persons, perhaps due to age-related comorbidities. More in depth analysis is planned.


Subject Category: C. Clinical studies of bacterial infections and antibacterials including sexually transmitted diseases and mycobacterial infections (surveys, epidemiology, and clinical trials)

Adam Robison, Aaron Smith and Charles Woods, MD, MS, Pediatrics, University of Louisville School of Medicine, Louisville, KY

Disclosures:

A. Robison, None

A. Smith, None

C. Woods, Pfizer: Grant Investigator, Research support

Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.