1133. Age-specific Incidence Rate in Severe or Symptomatic Infection due to Pandemic H1N1 2009 Influenza Virus
Session: Poster Abstract Session: Influenza and H1N1 Diagnosis, Epidemiology, and Viral Outcome
Saturday, October 22, 2011
Room: Poster Hall B1
  • Poster.pdf (777.5 kB)
  • Background:

    Age-specific incidence of the 2009 pandemic influenza provides the scientific basis of public health policies and the basic science research on the age-related susceptibility to influenza. While previous epidemiological studies provided vital information for public health policies, most did not incorporate age-specific data of asymptomatic, symptomatic and severe infection in the analysis. In this study, we incorporated data from seroprevalence and microbiologically-confirmed infection to estimate the relative impact of the pandemic influenza on various age groups.


    For the determination of pre-pandemic and post-pandemic seroprevalence, archived plasma samples randomly collected at the clinical biochemistry department of Queen Mary Hospital in the years 2007 and 2010 were used respectively. Microbiologically-confirmed cases and severe cases reported to the Centre for Health Protection (CHP) from May 1, 2009 to May 23, 2010 were included in our analysis. This study was approved by the institutional review board of the Hospital Authority of Hong Kong.


    795 and 1000 plasma samples were collected in 2007 and 2010 respectively. In 2007, 8.7% and 14.2% of individuals had HI titers ≥40 and ≥10 respectively. The pre-existing cross-reactive antibodies were mainly found in patients aged >70 years old. In 2010, the overall proportion of individuals with HI titers ≥40 and ≥10 is 23.2% and 42.2%. The highest overall microbiologically-confirmed incidence rate was found in the 0-10 year age group, and decreased with increasing age (ρ=-1.0, p<0.01). A total of 282 severe cases were reported with a mean age was 47.6 years. The incidence rate of severe cases showed an apparent bimodal age distribution, with higher incidence rate in the age group 0-10 and those older than 50 years old, and the highest incidence rate being those between 51 and 60 years old.


    While the young adults were most commonly infected, the clinical consequence is most alarming in children and older adults aged over 50 years. Public policies should continue to target this high risk group.

    Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

    Kelvin K. W. To, MBBS FRCPath1, Anna Zhang1, Herman Tse1, Kwok-Hung Chan1, Can Li1, Kun-yuan Guo1, Ivan F. N. Hung, MBChB FRCP2, Honglin Chen1, Sidney Tam3, Thomas Tsang4 and Kwok-Yung Yuen, MD1, (1)Microbiology, The University of Hong Kong, Hong Kong, Hong Kong, (2)Medicine, The University of Hong Kong, Hong Kong, Hong Kong, (3)Pathology, Queen Mary Hospital, Hong Kong, Hong Kong, (4)Centre for Health Protection, Kowloon, Hong Kong


    K. K. W. To, None

    A. Zhang, None

    H. Tse, None

    K. H. Chan, None

    C. Li, None

    K. Y. Guo, None

    I. F. N. Hung, None

    H. Chen, None

    S. Tam, None

    T. Tsang, None

    K. Y. Yuen, None

    Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.