1265. Schistosoma mansoni Bilharziosis in the Bafia Health District: electrophoretic profile of patients in Yorro
Session: Poster Abstract Session: Travel/Tropical Medicine and Parasitology
Saturday, October 22, 2011
Room: Poster Hall B1
Background: 

Schistosomiasis remains a public health problem in Cameroon, with the discovery of new foci every day.  However, this disease is still neglected by many clinicians, owing to its chronic evolution in most cases. Diagnosis is usually done by stool exam, with very limited follow-up. Dysproteinemias have been described in some parasitic diseases including trypanosomiasis (hypergammaglobulin M).   This work had the objective to update the Yorro focus (first described in 2001) and find out whether there were particular dysproteinemias linked with S. mansoni.

Methods: 

We carried out a prospective study between February 2009 and March 2010 among senior pupils in Yorro and a few community elders (Total sample size of 181 participants). Schistosomiasis was diagnosed by positive microscopy of the Schistosome ova in fresh stool samples. Serum protein electrophoresis was then carried out for some positive cases (30) and negative controls (15). A second electrophoresis was done in the case group one month after treatment with a single dose (40mg/kg) praziquantel.  Statistical analysis was done using Microsoft Excel 2007 and SPSS version 17 soft wares. P values were obtained using the two sample t- test. A p value of < 0.05 was considered statistically significant.

Results:

This study showed that Yorro is still an active S.mansoni focus with prevalence of 33.1%; however, parasite loads

were not as high (40-180eggs per gram of stool). Some protein disorders were found in our patients (hypoproteinemia, hypergammaglobulinemia, hypo alpha 2 globulinemia, Prominent beta peaks), with some amelioration but not complete regression after treatment. There were also some abnormalities in some of our controls though; an indication that confounders were not completely eliminated or that there were some false negative cases.

Conclusion: 

Schistosoma mansoni infections are responsible for modifications of protein electrophoresis.


Subject Category: T. Travel/tropical medicine and parasitology

Christella Ajong, MD, MEDICAL WARD, BUEA REGIONAL HOSPITAL, BUEA, Cameroon

Disclosures:

C. Ajong, None

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