377. Antibiotic Resistance Trends of Bloodstream Infection Isolates in Intensive Care Units in Korea: results from a Korean Nosocomial Infections Surveillance System (KONIS)
Session: Poster Abstract Session: Epidemiology - Bacterial Infections
Friday, October 21, 2011
Room: Poster Hall B1

Background: To know the regional resistance pattern of nosocomial pathogens is important for planning the infection control strategy. We describe the trend of antimicrobial resistance of bloodstream infection isolates in intensive care units in Korea from 2006 to 2010.

Methods: Korean Nosocomial Infections Surveillance System (KONIS) performed prospective surveillance for bloodstream infection (BSI) in intensive care units (ICU) in Korea from 2006 to 2010. The definitions of BSI was standardized and based on that of NNIS system, CDC, USA. Nine selected resistant pathogens (Methicillin for Staphylococcus aureus [MRSA]; vancomycin for Enterococcus faecalis [VREFA] and Enterococcus faecium [VREFM]; cefotaxime and ciprofloxacin for Escherichia coli [CTXREC and CIPREC] and Klebsiella pneumonia [CTXRKP and CIPRKP]; imipenem for Pseudomonas aeruginosa [IRPA] and Acinetobacter baumannii [IRAB]) were compared using incidence density per 100,000 patient-days. Trend for linearity was calculated by EpiInfo version 6 (CDC, USA).

Results: A total of 1,702,984 patient-days were reviewed and 3,624 BSI were observed. MRSA (n=690) was a major BSI pathogen followed by VREFM (n=178) and IRAB (n=102) during 4 years. Incidence density of each resistant pathogen was significantly increased in CTXREC (1.59 to 4.59, p = 0.01) and IRAB (8.34 to 18.00, p = 0.00).

Conclusion: During 2007 to 2010 in Korean ICUs, antimicrobial resistance in Nosocomial BSI isolates was increasing in CTXREC and IRAB.

Pathogens

Year

P value

Total

2007

2008

2009

2010

MRSA

36.12 (91)

44.94 (192)

48.57 (222)

32.65 (185)

0.00

40.52 (690)

VREFA

0.00 (0)

1.40 (6)

0.66 (3)

0.35 (2)

0.10

0.65 (11)

VREFM

11.51 (29)

7.02 (30)

11.81 (54)

11.47 (65)

0.09

10.45 (178)

CTXREC

1.59 (4)

1.64 (7)

2.19 (10)

4.59 (26)

0.01

2.76 (47)

CTXRKP

2.78 (7)

3.98 (17)

5.25 (24)

4.41 (25)

0.49

4.29 (73)

CIPREC

1.98 (5)

1.87 (8)

1.09 (5)

2.29 (13)

0.56

1.82 (31)

CIPRKP

3.57 (9)

2.81 (12)

3.28 (15)

2.29 (13)

0.72

2.88 (49)

IRAB

8.34 (21)

12.40 (53)

14.44 (66)

18.00 (102)

0.00

14.21 (242)

IRPA

0.79 (2)

0.47 (2)

0.88 (4)

0.18 (1)

0.43

0.53 (9)

Patient-days

251,947

427,268

457,098

566,671

1,702,984

Each data shows incidence density per 100,000 patient-days (No. of cases)


Subject Category: N. Hospital-acquired and surgical infections, infection control, and health outcomes including general public health and health services research

Jin Yong Kim, MD1, Yong Kyun Cho, MD1, Sang-Oh Lee, MD2, Yee Gyung Kwak, MD3, Mi Suk Lee, MD4, Joong Sik Eom, MD5, Eun Suk Park, RN6 and Sun Young Jeong, RN7, (1)Gachon University Gil Hospital, Incheon, South Korea, (2)Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, (3)Department of Internal Medicine, Inje University College of Medicine, Busan, South Korea, (4)Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, South Korea, (5)Kangdong Sacred Heart Hospital, Hallym University, Seoul, Korea, Republic of, (6)Severance Hospital, Seoul, South Korea, (7)Ewha Womans University Mokdong Hospital, Seoul, South Korea

Disclosures:

J. Y. Kim, None

Y. K. Cho, None

S. O. Lee, None

Y. G. Kwak, None

M. S. Lee, None

J. S. Eom, None

E. S. Park, None

S. Y. Jeong, None

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