880. Association between gastric Helicobacter pylori colonization and glycated hemoglobin levels in two National Health and Nutrition Examination Surveys
Session: Oral Abstract Session: Microbiome and Susceptibility to Infection
Saturday, October 22, 2011: 11:15 AM
Room: 156ABC
Background: The literature on the relationship between H. pylori colonization and diabetes are inconsistent; however, studies that evaluated the potential influence of H. pylori on biomarkers for diabetes are lacking. 

Methods: We conducted cross-sectional analyses using data from 7,417 participants in the National Health and Nutrition Survey (NHANES) III (age ≥ 18y) and 6,072 participants in NHANES 1999-2000 (age ≥ 3y) to assess the association between H. pylori and levels of glycosylated hemoglobin (HbA1c).  NHANES III included ascertainment for H. pylori cagA status, while NHANES 1999-2000 did not.

Results: H. pylori seropositivity, especially H. pylori cagA-positivity, was positively associated with HbA1c levels after excluding individuals with history of diabetes (p < 0.01 for NHANES 1999-2000 and p = 0.02 for NHANES 1999-2000), controlling for age, gender, race-ethnicity, body mass index (BMI), smoking status, and educational attainment. From NHANES 1999-2000, we saw that all of the effects were in persons >18y. In addition, there was a synergistic interaction between H. pylori and higher levels of BMI, such that the increased levels of HbA1c associated with having both H. pylori and a higher BMI were greater than the sum of their individual effects (p for interaction < 0.01).  This interaction was observed consistently in both NHANES III and NHANES 1999-2000 and for H. pylori cagA-positivity in NHANES III.  However, there was no association between H. pylori and history of self-reported diabetes. 

Conclusion: 

The findings indicate a role of H. pylori in impaired glucose tolerance in adults that may be potentiated by higher BMI level.


Subject Category: C. Clinical studies of bacterial infections and antibacterials including sexually transmitted diseases and mycobacterial infections (surveys, epidemiology, and clinical trials)

Yu Chen, PhD, MPH and Martin Blaser, MD, FIDSA, New York University School of Medicine, New York, NY

Disclosures:

Y. Chen, None

M. Blaser, None

Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.