316. In Vivo Randomized Comparison of the Immediate and Persistent Efficacies of a Brushless, Waterless, Dual-Active Surgical Hand Antiseptic versus Two Brushless, Waterless, Alcohol Surgical Hand Antiseptics According to ASTM E1115
Session: Poster Abstract Session: Assessing and Reducing Infection Risk
Friday, October 21, 2011
Room: Poster Hall B1
  • IDSA-Hand Hygiene_HR.pdf (939.4 kB)
  • Background: Surgical site infections (SSIs) are the second most common type of healthcare-associated infection (HAI) in the United States and are a serious medical problem associated with extended length of stay, increased medical costs, and significant morbidity and mortality. One of the key strategies for reducing the risk of SSIs is to prevent potential contamination of the wound by microorganisms on the hands of the surgical team. The introduction of waterless, brushless surgical hand scrubs has resulted in important opportunities to decrease the time required for hand preparation and the amount of skin damage caused by the traditional scrubbing procedure.

    Methods: The immediate and persistent efficacies of a waterless, brushless, dual-active surgical hand antiseptic were compared against those of two waterless, brushless, alcohol surgical hand antiseptics, one of which contains preservative levels of chlorhexidine gluconate (CHG) and benzalkonium chloride (BZK), using ASTM E1115, Standard Test Method for Evaluation of Surgical Hand Scrub Formulations. Each test material was applied 12 times over a 5-day period. Samples were collected twice on Days 1 and 5, immediately after the product finished drying and 6 hours later. Subjects were randomly assigned to use one of the three test materials and samples of aerobic bacteria were collected using the glove juice technique. Relative suppression of regrowth was compared using a paired t test.

    Results: Mean baseline counts were 6.1, 6.2, and 6.1 log10 colony-forming units (CFU) per hand for subjects receiving the dual-active product, the alcohol product without CHG and BZK, and the alcohol product with CHG and BZK, respectively. Mean log counts obtained for the day 1, immediate sample; day 1, 6-hour sample; day 5, immediate sample; and day 5, 6-hour sample were 3.6, 3.2, 3.5, and 3.1 log10 CFU/hand for the dual-active product; 3.8, 5.1, 3.7, and 4.6 log10 CFU/hand for the alcohol product without CHG and BZK; and 4.0, 4.6, 3.6, and 3.7 log10 CFU/hand for the alcohol product with CHG and BZK, respectively.

    Conclusion: The dual-active product was found to be noninferior to the alcohol products at all sampling times, but showed persistence superior to that of both after 6 hours of glove wear (P<.03).

    Subject Category: N. Hospital-acquired and surgical infections, infection control, and health outcomes including general public health and health services research

    Collette Duley, BS1, Linda Olson, BS2 and Dan Morse, MS2, (1)BioScience Laboratories, Inc., Bozeman, MT, (2)Infection Prevention Division, 3M Health Care, St. Paul, MN


    C. Duley, 3M Health Care: Research Contractor, Research support

    L. Olson, 3M Health Care: Employee, Salary

    D. Morse, 3M Health Care: Employee, Salary

    Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.