1290. Identification of adenoviral serotypes in basic military trainees at Lackland Air Force Base
Session: Poster Abstract Session: Viral Epidemiology
Saturday, October 22, 2011
Room: Poster Hall B1
Background: Of the seven species (A to G) of human adenoviruses (HAdVs), species B, C, and E can cause febrile respiratory illness (FRI).  While species C usually affects pediatric populations, species B and E are responsible for the majority FRI among basic military trainees (BMTs).  Annually, HAdVs cause 22,000 FRI cases in BMTs requiring medical attention.  These cause training schedule delays costing the US government $40M annually.

Methods: BMTs at Lackland AFB (LAFB) with FRI symptoms volunteered nasal washes, throat swabs, and standardized questionnaires under IRB-approved protocols.  Samples were tested with a panel of quantitative PCR assays including ones to detect HAdV serotypes B3, E4, B7, B11, B14, and B21.

Results: 1514 of 2138 FRI cases typed between May 2007 and March 2011 were HAdV positive (71%).  Two predominant subtypes were observed, and their outbreaks overlapped: 404 cases of HAdV-B14 occurred between May 2007 and July 2009, while 983 cases of HAdV-E4 occurred between January 2009 and March 2011.  Additionally, 94 cases of HAdV-B7 were also observed between October 2008 and May 2009.  Similarly, small occurrences of HAdV-B3 were observed, with 12 cases identified between November 2008 and February 2009, 7 cases in June 2010, and 9 cases in January and February 2011.

Conclusion: The pathogens causing most FRI cases in BMTs at LAFB are HAdVs.  The recently FDA approved adenovirus vaccine is likely to change the respiratory pathogen landscape for the BMT.  It is essential to characterize respiratory infections so that the epidemiology of respiratory outbreaks is known.

“ The opinions expressed on this document are solely those of the author(s) and do not represent an endorsement by or the views of the United States Air Force, the Department of Defense, or the United States Government.”


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

J. Matthew McDonald, PhD1, Lisa Lott, PhD1, Thomas L. Cropper, DVM2, Heather Yun, MD3 and Debra Niemeyer, Ph.D.4, (1)Eagle Applied Sciences Advanced Diagnostics Laboratory, 59th Medical Wing, Lackland AFB, TX, (2)Trainee Health Surveillance, Lackland AFB, TX, (3)San Antonio Military Medical Center, Fort Sam Houston, TX, (4)Chief Scientist Office, 59th Medical Wing, Lackland AFB, TX

Disclosures:

J. M. McDonald, None

L. Lott, None

T. L. Cropper, None

H. Yun, None

D. Niemeyer, None

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