593. Extended antimicrobial activity and prolonged durability of combination chlorhexidine (CHX) and minocycline/rifampin (M/R) coated vascular central venous catheters (CVC)
Session: Poster Abstract Session: Novel Antimicrobial Agents
Friday, October 21, 2011
Room: Poster Hall B1
Handouts
  • 593_LauraClaburn_sm.pdf (2.1 MB)
  • Background: M/R CVCs have been shown to be efficacious in reducing catheter-related bloodstream infections with excellent inhibitory activity against biofilm formation by staphylococci and most Gram-negative bacilli.   A limitation is the lack of activity against Pseudomonas aeruginosa (PA) and Candida sp.  An improved coating was developed by sequential addition of chlorhexidine to M/R (CHX-M/R).   CHX-M/R CVCs were compared against FDA-approved M/R, CHX/Silver Sulfadiazine (CHX/SS) CVCs.

    Methods: CHX-M/R CVCs were coated for 4hr with a novel combination of CHX-M/R.  Antimicrobial durability of M/R, CHX/SS and CHX-M/R coated CVCs was determined against methicillin-resistant Staphylococcus aureus (MRSA), PA, Candida albicans (CA) and Candida glabrata (CG) by immersion for 3 weeks in serum with weekly challenges in a biofilm colonization model.

    Results: CHX-M/R had significantly more effective antimicrobial durability against MRSA and PA than the M/R, CHX/SS, and uncoated CVCs (P<0.0001) for 3 weeks (see Figure).  CHX-M/R and CHX/SS CVCs had effective antimicrobial durability against CA and CG versus M/R (data not shown below).  

    Conclusion:  CHX-M/R-CVC had prolonged antimicrobial durability and completely inhibited biofilm colonization of the multi-resistant bacteria and fungi when compared to coated M/R, CHX/SS and uncoated catheters.


    Subject Category: A. Antimicrobial agents and Resistance

    Jamal Mohamed, PhD, Anne-Marie Chaftari, MD, Ruth Reitzel, MS, Ying Jiang, MS, Tanya Dvorak, Ray Hachem, MD and Issam Raad, MD, Infectious Diseases, Infection Control & Employee Health, University of Texas MD Anderson Cancer Center, Houston, TX

    Disclosures:

    J. Mohamed, None

    A. M. Chaftari, None

    R. Reitzel, None

    Y. Jiang, None

    T. Dvorak, None

    R. Hachem, None

    I. Raad, Cook: Grant Investigator and Speaker's Bureau, Licensing agreement or royalty

    Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.