1130. Secondary Respiratory Viral Infections (RVI) in Freshman Dormitories During the H1N1 Pandemic
Session: Poster Abstract Session: Influenza and H1N1 Diagnosis, Epidemiology, and Viral Outcome
Saturday, October 22, 2011
Room: Poster Hall B1
Background: 

Respiratory viral infections are prevalent on college campuses. The Novel H1N1 pandemic highlighted an increasing need to control and monitor transmission amongst students living in a communal dormitory setting. During the H1N1 pandemic, an index cluster study was conducted to assess risk factors for secondary transmission of RVI on a freshman campus. This study also provided information concerning other ILI’s that were present among students in addition to the apparent novel H1N1 flu strain.

Methods: 

A subject qualified as an index case(IC) when their symptom score (aggregated modified Jackson score gauging 8 symptoms on a 0-4 severity scale) reached a threshold indicative of illness onset. Once IC’s were identified, close contacts (people living in the same dorm as the corresponding IC, CC’s), were chosen based on a recent history of negligible symptom scores. Each IC corresponded to between 3 and 26 close contacts. We monitored CC’s for symptomatic and virologic conversion (using the Qiagen Resplex II v2.0 platform) Etiology data was also correlated with individual health history/social/demographic factors, including but not limited to gender, flu vaccine status, interpersonal proximity, and academic stressors.

Results: 

We selected 13 index clusters, comprised of 35 IC’s and 187 CC’s.  19/35 IC’s displayed positive viral etiology, and we identified a causative virus in 10/13 clusters (Rhinovirus (5), Novel H1N1 (5), Coxsackie/Echovirus (CV/EV) (5), and Coronavirus OC43 (1)). Multiple viruses were detected in 6 IC’s. Of the 187 close contacts, 28 had detectable virus, a secondary infection rate of 14.97%. 16 of these 28 matched the etiology of their corresponding IC (conversion rate = 57.14%). Few cases of H1N1 were identified during the pandemic.  However an outbreak of CV/EV was observed in one of the clusters, 3 IC’s and 5 /17 close contacts testing positive, (conversion rate = 29.41%).

Conclusion: 

This study demonstrates a need for further research into risk factors of disease transmission on college campuses. The attack rates were highest in non-H1N1 cases, highlighting a need to consider non-influenza ILI during pandemic response.


Subject Category: V. Virology including clinical and basic studies of viral infections, including hepatitis

Monica Jimenez, MPH1, Stephanie Dobos, BA1, Sara Hoffman, BSN2, Ryan Mather, BS1, Brad Nicholson, PhD3 and Christopher Woods, MD, MPH4,5, (1)Institute for Medical Research, Durham, NC, (2)Durham Va Medical Center, Durham, NC, (3)Durham VA Medical Center, Durham, NC, (4)Durham Veterans Affairs Medical Center (DVAMC), Durham, NC, (5)Duke University Medical Center, Durham, NC

Disclosures:

M. Jimenez, None

S. Dobos, None

S. Hoffman, None

R. Mather, None

B. Nicholson, None

C. Woods, None

Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.