1142. The Relationship Between Brucellosis and Vitamin D
Session: Poster Abstract Session: Innate and Adaptive Immunity to Infections
Saturday, October 22, 2011
Room: Poster Hall B1
Background: Vitamin D regulates immune system and functions of macrophages. Vitamin D deficiency leads to decrease in proinflammatory cytokine production an deteriorates  chemo taxis and phagocytosis. This study aimed to define to role of vitamin D and soluble vitamin D receptor (VDR) levels in patients with brucellosis which is a very common disease in Turkey.

Methods: Eighty-six patient who were diagnosed with brucellosis between May 2009 and December 2010 and 86 control patients older than 18 year were included in the study. 25 OH vitamin D3, and soluble VDR levels were compared between patients with brucellosis and control group. Also clinical characteristic and course of disease were evaluated. 

Results: Eighty-six patients with brucellosis 44%male with a mean age of 40±18 were compared with eighty-six control subjects with similar age and gender. Among patients with brucellosis, 33% revealed blood culture positivity, 22% were sacroiliitis, 22% were spondylitis, 5% was determined to have neurological involvement. Acute, subacute and chronic disease was determined in 84, 13 and 3% of the patients, respectively. The mean value of 25 OH vitamin D3 level was significantly lower in patients than controls  (23 ± 13 ng/ml vs 30  ± 16 ng/ml, p< 0.05). As well, VDR level was also lower in patients than controls (1.21 ± 1.04 vs 1.77 ±  1.10, p=0.0001). When the patients  with or without any complication due to brucellosis compared, no significant difference was found.

Conclusion: In conclusion, this study is first study to show that vitamin D3, VDR with brucellosis relation. This may indicate that 25 OH vitamin D3 may be an important issue at the pathogenesis of the disease.


Subject Category: E. Innate and adaptive immunity to infections, including vaccine immunology

Ozay Akyildiz, Behice Kurtaran, Aslihan Candevir, Ayse Seza Inal, Akgun Yaman, Hasan Salih Zeki Aksu, Gulsah Seydaoglu and Yesim Tasova, Cukurova University, Adana, Turkey

Disclosures:

O. Akyildiz, None

B. Kurtaran, None

A. Candevir, None

A. S. Inal, None

A. Yaman, None

H. S. Z. Aksu, None

G. Seydaoglu, None

Y. Tasova, None

Findings in the abstracts are embargoed until 12:01 a.m. EST Thursday, Oct. 20 with the exception of research findings presented at IDSA press conferences.