281. Sodium Oxychlorosene 0.2% Bladder Irrigation for Treatment of Patients with Urinary Tract Infections (UTIs)
Session: Poster Abstract Session: Antimicrobial Therapy: Clinical Studies
Friday, October 21, 2011
Room: Poster Hall B1
Background: Urinary tract infections (UTIs) are common in hospitalized patients, including those with indwelling urinary catheters. Increasingly, patients are developing infections with resistant organisms, forcing the use of costly, broad-spectrum antibiotics to treat them. Use of systemic antibiotics may also contribute to resistance and increase the risk for secondary infections such as  toxin-producing Clostridium difficile. One of the methods for combating these problems is to reduce systemic exposure to antibiotics. Sodium oxychlorosene is a topical antiseptic used for treating localized infections. Sodium oxychlorosene has activity against both gram-positive and gram-negative bacteria, fungi, yeast, mold, viruses, spores, and may be especially useful against multi-drug resistant organisms.  Sodium oxychlorosene is currently available in the United States.  The objective of this analysis was to characterize the use of 0.2% sodium oxychlorosene solution as a local bladder irrigation for treatment of patients with UTIs.

Methods: Data were collected by retrospective chart review.  Patients included in analysis were treated with sodium oxychlorosene during 2005-2010 for the diagnosis of UTI. Sodium oxychlorosene regimen, duration of therapy, and patient outcomes were assessed.  Outcome was determined at the end of hospital stay as cure, improved, or failure.

Results: Twenty-five patients were included for analysis. Baseline urine culture identified 33 organisms, including 13 multidrug resistant bacteria and 9 isolates of Candida sp.  Success rate (cure + improved) was 84%. The most frequently used regimen consisted of 2 bladder instillations via a urinary catheter every 12 hours. Mean duration of therapy (days) and number of treatments were 2.62 and 4.68, respectively.  Seven patients had repeat urine cultures and 81.8% resulted clear or improved. Seven patients (28%) experienced adverse effects while receiving treatment with sodium oxychlorosene, with discomfort occurring most frequently and leading to one discontinuation of therapy. 

Conclusion: Short courses of sodium oxychlorosene appear to be an effective treatment for UTIs, including those due to multidrug resistant bacteria and yeast.


Subject Category: A. Antimicrobial agents and Resistance

Megan Fleming, PharmD and S. Christian Cheatham, PharmD, Pharmacy, St. Francis Health, Beech Grove, IN

Disclosures:

M. Fleming, None

S. C. Cheatham, None

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