869. Dissecting Neutralizing Monoclonal and Polyclonal Antibodies Against Dengue Virus
Session: Symposium: Neutralizing Antibodies for Viruses
Saturday, October 22, 2011: 11:15 AM
Room: 253ABC

Eva Harris, PhD, University of California, Berkeley, Berkeley, CA

Dr. Eva Harris is currently a Professor in the Division of Infectious Diseases and Vaccinology and Director of the Center for Global Public Health in the School of Public Health at the University of California, Berkeley. She received a BA in Biochemical Sciences from Harvard University and a PhD in Molecular and Cell Biology at the University of California, Berkeley. After a post-doctoral fellowship and Assistant Adjunct Professorship at UC San Francisco, Dr. Harris joined the faculty at UC Berkeley and developed a multidisciplinary approach to study the molecular virology, pathogenesis, and epidemiology of dengue, the most prevalent mosquito-borne viral disease in humans. Her laboratory at UC Berkeley studies dengue virus replication and host cell-virus interations; specifically, the mechanism of dengue virus translation, the role of RNA structural elements in virus replication, and dengue virus infection of human dendritic cells. Another research focus has been the development of a mouse model to study viral tropism and pathogenesis, investigate the immune response to dengue virus infection, and generate a better model of disease. Her field work focuses on laboratory-based and epidemiological studies of dengue in endemic Latin American countries, particularly in Nicaragua, where ongoing projects include clinical and biological studies of severe dengue, a pediatric cohort study of dengue transmission in Managua, and a project on evidence-based, community-derived interventions for prevention of dengue via control of its mosquito vector. This work has led to studies of dengue pathogenesis in humans, focusing on functional characterization of antibodies and B cell memory response, host gene expression profiling, and viral factors such as quasispecies. She has also collaborated with investigators in the Department of Electrical Engineering at UC Berkeley to develop the ImmunoSensor, a novel, rapid, low-cost diagnostic device for point-of-care diagnosis of dengue and other infectious diseases.
In 1997, Dr. Harris received a MacArthur “Genius” Award for her pioneering work over the previous ten years developing programs and working to build scientific capacity in developing countries to address public health and infectious disease issues. To continue and expand this work, in 1998 she founded a non-profit organization in San Francisco, Sustainable Sciences Institute (SSI; www.ssilink.org) and published a book on the subject with Oxford University Press. She was co-Director of the Fogarty International Center's "International Training and Research in Emerging Infectious Diseases" program at UC Berkeley from 1997-2003. In 2001, Dr. Harris was named a Pew Scholar for her work on dengue pathogenesis. In 2002, she received the Prytanean Faculty Award for outstanding women faculty as well as a national recognition award from the Minister of Health of Nicaragua for her contribution to scientific development, and she was selected as a Global Leader for Tomorrow by the World Economic Forum. She is currently Director of the new Center for Global Public Health at UC Berkeley. Dr. Harris has published over 90 peer-reviewed articles, as well as a book on her international scientific work.

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