79. The Next Century of Mycobacterial Disease Studies: Will Host Genetic Studies Hold the Key?
Session: Symposium: Your Genome and Infections: What Has the Genomic Revolution Provided for the ID Clinician?
Thursday, October 18, 2012: 9:30 AM
A number of key technological developments have enabled high throughput genomic studies of infectious disease susceptibility. These studies, in turn, have yielded important discoveries of human genes associated with immunity to specific pathogens, and soon studies will be possible which compare whole human genome sequencing with whole pathogen sequencing to understand the genetics underlying the ability of pathogens to infect humans. In this presentation studies related to human susceptibility to tuberculosis and leprosy will be highlighted. In a broader sense, the presentation will also demonstrate how modern genomics will directly impact on the clinical diagnosis of patients within the near future and results will be presented from the Vannberg lab which demonstrates a novel clinical metagenomic pipeline for precisely diagnosing infections from circulating nucleic acids and bronchial alveolar lavage. In the future, genomics will play an ever increasingly expanding role in clinical practice within the ID community. This presentation will highlight how this transformation will not only help researchers understand the basic science behind the host pathogen relationship, but also help clinicians better diagnose and precisely treat patients.
Fredrik Vannberg, PhD, Georgia Institute of Technology, Atlanta, GA

Dr. Fredrik Vannberg is an Assistant Professor at the Center for Integrative Genetics at Georgia Institute of Technology, School of Biology, and an Associate Fellow of Green Templeton College, Oxford University. Dr. Vannberg's career focuses on using computational genetics to study the host pathogen relationship. He obtained his doctoral degree with Prof. Adrian Hill at Oxford University where he led genome wide association studies on tuberculosis and leprosy, as well as computational approaches to understand gene regulation in the context of innate immune stimulation. His research is published in New England Journal of Medicine, Nature Genetics, PLoS Genetics and other top journals. His research at Georgia Tech continues to focus on computational approaches to define novel genes important in immunity to mycobacterial diseases and HIV. In addition, his laboratory is aggressively pursuing clinical metagenomic approaches to diagnose infections using next generation sequencing of circulating nucleic acids from normally sterile sites.

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