1763. Respiratory Tract Viral Infections in Hospitalized Patients in Kuwait
Session: Poster Abstract Session: Viral Infections; Pathogenesis and Epidemiology
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
Posters
  • 1763_IDWPOSTER1.pdf (802.4 kB)
  • Background:

    Respiratory infections are a major cause of morbidity and mortality in developing countries especially in infants, children and elderly. The majority of  respiratory tract infections (RTI) are caused by viruses. Little is known about the role of respiratory viruses in causing RTI in Kuwait.

    Methods:

    Clinical specimens from 735 patients admitted with RTI were investigated for the presence of 14 respiratory viruses by multiplex PCR (mPCR) and Real-time PCR (RT-PCR). mPCR for influenza A virus (Flu A), respiratory syncytial virus (RSV), human rhinovirus (HRV), adenoviruses (AdV), parainfluenza virus (PIV)-1& PIV-3. Real-time PCR (RT-PCR) for the detection of HCoV-229E, HCoV-C43, HCoV-NL63, Boca, hMPV, KIV and WUV.

    Results: Over the past three years, of the 735 patients with RTI 285 (38.8%) had viral RTI. Of these 42.8% (n=122), 16.5% (n=47) and 14.7% (n=42) were due to HRV, FluA and RSV, respectively. Furthermore, 7.7% (n=22), 3.5% (n=10) and 2.1% (n=6) were due to AdV, PIV-3 and PIV-1 respectively. Among the newly discovered viruses HCoV-OC43 gave the highest incidence 8.8% (n=25). In addition, 5.3% (n=15) of RTI were caused by hMPV; 4.9% (n=14) by HCoV-229E ; 4.9% (n=14) by Boca; 3.5% (n=10) by WUV; and 1.4% (n=4) by KIV.  None of the patients investigated for HCoV-NL63 were found to be positive. The majority of respiratory viral infections, 61% (n=202) were among patients aged ≤5 year (Table 2). the majority of patients were admitted with Lower RTI (263 or 79.5% of infections) rather than Upper RTI (68 or 20.5% of infections) . Most of our hospitalized patients were seen during October to June. 

    Conclusion:

    1.mPCR and RT-PCR assays provided a rapid, specific and sensitive methods 
    2.Our study clearly showed that 38.8% had viral RTI, 42.8% of these patients had HRV 
    3.FluA is the next most common viral infection where it was detected in 16.5% of hospitalized patients with RTI.
    4.Among the newly discovered viruses HCoV-OC43 gave the highest incidence 8.8% followed by hMPV 5.3%.
    5.The majority of hospitalized patients with respiratory viral infections, 61% were among patients ≤5 years of age.
    6.The majority of patients were admitted with Lower RTI 79.5% rather than Upper RTI 20.5%.
    7.Respiratory viral infections incidences is high in the winter months and generally peaks during December and January.
    Haya Altawalah, BSc. MBBS. FRCPath Clinical Virology, Virology Unit, Faculty of Medicine, KUWAIT, Kuwait

    Disclosures:

    H. Altawalah, None

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