1244. Trends in the burden of CMV hospitalizations in the US, 2001-2010
Session: Oral Abstract Session: Hot Topics in Public Health
Saturday, October 5, 2013: 10:30 AM
Room: The Moscone Center: 220-226
Background: The burden of cytomegalovirus (CMV)-associated illness is considerable in the US and worldwide. Traditionally thought to be confined to newborns and organ transplant recipients, more recent data suggest that CMV has clinical implications among hospitalized non-transplant patients. Given this potentially broader association with morbidity and mortality in some hospitalized populations, we set out to understand trends in the overall burden of CMV in the hospital.

Methods: We conducted a time series analysis in a large US hospital database between years 2001 and 2010. HCUP-NIS is a nationally representative 20% sample of all non-federal hospitalizations in the US. Aggregate data are publicly available and represent the entire complement of US hospital discharges. CMV was identified using the ICD-9-CM code 078.5. Using censal and intercensal population estimates obtained from the Census Bureau, we calculated age-stratified population incidence of hospitalizations with CMV. Results are reported as point estimate +/- standard error of the mean.

Results: The total number of CMV discharges rose from 10,904 +/- 940 in 2001 to 18,537 +/- 1,922 in 2010. After a period of quiescence from 2001 to 2006, there was an acceleration of growth between 2006 (10,938 +/ 933) and 2010 (18,537 +/- 1,922). In the age-stratified population analysis (<18, 18-44, 45-64, 65-84, 85+ years), the most robust growth was noted among the 65-84 years-of-age group going from 2.45 +/- 2.21 to 9.37 +/- 8.21 discharges per 100,000 population between 2001 and 2010. Second greatest growth was noted in the 45-64 years-of-age group (5.77 +/- 0.66 in 2001 to 9.19 +/- 1.16 in 2010). The eldest age group’s rate rose from zero in 2003-2006 to 2.13 +/- 0.61 per 100,000 population in 2010. The two youngest age groups exhibited the smallest magnitude of growth.  

Conclusion: CMV represents a growing burden among hospitalized patients in the US. Over the last 5 years there has been a shift in the age distribution of CMV hospitalizations from younger to older age groups, with the oldest group (age 85+ years) undergoing considerable growth. Although our data are generalizable, it is probable that they underestimate the true burden of CMV hospitalizations.

Marya D. Zilberberg, MD, MPH, University of Massachusetts and Evimed Research Group, LLC, Goshen, MA, Paresh Chaudhari, PharmD, Astellas Pharma US, Inc., Deerfield, IL and Andrew F. Shorr, MD, MPH, Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC


M. D. Zilberberg, Astellas: Consultant and Investigator, Research grant

P. Chaudhari, Astellas: Employee and Shareholder, Salary

A. F. Shorr, Astellas: Consultant, Consulting fee

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