946. Clinical Presentation, Risk Factors and Hospital Course in Children Infected With Human Bocavirus (HBoV) in South Texas
Session: Poster Abstract Session: Respiratory Infections
Friday, October 4, 2013
Room: The Moscone Center: Poster Hall C
  • BOCAVIRUS_POSTER-9 27.pdf (279.1 kB)
  • Background: Human bocavirus (HBoV) is a newly recognized parovirus discovered in 2005. The worldwide presence of HBoV infection in children has been confirmed, however, clinical characteristics and importance of HBoV are still unclear. The goals of this study were to understand the clinical features, relative importance as well as underlying illnesses in children infected with HBoV in South Texas.

    Methods: We identified all children who had a positive result for HBoV in a nasopharyngeal swab between November 2011 and February 2013 at Driscoll Children’s Hospital clinical laboratory in Corpus Christi, Texas. A total of 4473 nasopharyngeal swab were collected and screened by polymerase chain reaction assay for the genomes of 19 respiratory viruses and bacteria. The medical records were reviewed for demographic and clinical data.

    Results: HBoV DNA was identified in 222 samples (4.9%). 162 patients were co-infected with other viruses (Enterovirus/Rhinovirus 38.3%, RSV 18.5%,Adenovirus 8.5%,Parainfluenza 8.5%) or bacteria (2.2%).Total co-infection rate 73%. Bocavirus ranked 5th in identification frequency behind Rhinovirus/Enterovirus, RSV, Parainfluenza and Influenza B viruses. The peak season for HBoV infection occurred from November through February. Sixty percent of the children were males. Seventy five percent were less than 1 year old. Fifty five percent of the children were hospitalized. The mean length of stay was 2.5 days. Children with prematurity, asthma, chronic lung disease or congenital heart disease were more likely to be admitted and had a more prolonged hospitalization than children without these underlying conditions. The most common symptoms were cough, fever, rhinorrhea and respiratory distress. Other symptoms included diarrhea, vomiting and rash.  Leukocytosis was presented in forty percent of patients. Chest x-rays reported peribronchial cuffing, interstitial infiltrates and hyperinflation. Consolidation and pleural effusion were not detected.

    Conclusion: HBoV is an important respiratory pathogen in South Texas children, primarily affecting infants, and it is more frequently detected in males. Most cases occurred during winter. Co infections are common. Prematurity, asthma, chronic lung disease and congenital heart diseases were associated with more severe infection.

    Na Liu, MD1, Karla Araujo, MD2, Kevin Richman, BS, MT3, Charles Raven, BS, MT3,4 and Jaime Fergie, MD5, (1)Pediatrics, Driscoll Children's Hospital, Corpus Christi, TX, (2)Pediatric, Driscoll Children's Hospital, Corpus Christi, TX, (3)Laboratory Medicine, Driscoll Children's Hospital, Corpus Christi, TX, (4)Laboratory Medicine, Driscoll Children's Hopital, Corpus Christi, TX, (5)Driscoll Children's Hospital, Corpus Christi, TX


    N. Liu, None

    K. Araujo, None

    K. Richman, None

    C. Raven, None

    J. Fergie, None

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