250. High Prevalence of Penicillin Non-susceptable Streptococcus pneumoniae Isolates from Clinical Respiratory Specimens in Gangwon province, Korea
Session: Poster Abstract Session: Diagnostic Microbiology; Antimicrobial Sensitivities
Thursday, October 3, 2013
Room: The Moscone Center: Poster Hall C
  • IDSA2013.pdf (1.4 MB)
  • Background: After the revision of penicillin breakpoints for Streptococcus pneumoniae by the Clinical and Laboratory Standards Institute (CLSI) in 2008, the penicillin non-susceptible rate of S. pneumoniae had become very low. We evaluated the impacts of the new penicillin breakpoints on the susceptibility rate of S. pneumoniae isolated from clinical respiratory specimens.

    Methods: From 2007 to 2011, 571 non-duplicated S. pneumoniae strains were isolated from the patients’ respiratory specimens at Wonju Severanace Christian Hospital, Yonsei University Wonju College of Medicine located Gangwon province, South Korea. The MIC breakpoints were determined by microdilution and the susceptibilities were determined by the CLSI interpretive criteria. 

    Results: Of 571 S. pneumoniae isolates, 268 were isolated from patients with pneumonia and 303 were isolated from patients without pneumonia. Penicillin MIC of 69 (12.1%) isolates was ≤ 0.06 ug/mL and that of 366 (64.1%) isolates was ≤ 2 ug/mL. The susceptible rates for ceftriaxone, cefepime, levofloxacin and meropenem were 69.4%, 49.6%, 89.7%, 22.8%, respectively. The absolute categorical agreement between penicillin and ceftriaxone was 78.4%. 

    Conclusion: According to revised penicillin breakpoints for S. pneumoniae, the penicillin non-susceptible rate was decreased from 87.9% to 35.9%, however, it was still relative high.

    Young Keun Kim, MD, PhD, Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea, Young Uh, MD, PhD, Dept. of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea, Seok Hahn, MD, Dept. of Radiology, Wonju College of Medicine, Yonsei University, Wonju, South Korea, Hee Kyoung Choi, AIDS Res.Inst., Seoul, Korea, Republic of and Hyo Youl Kim, MD, PhD, Division of Infectious Diseases, Yonsei University Wonju College of Medicine, Wonju, South Korea


    Y. K. Kim, None

    Y. Uh, None

    S. Hahn, None

    H. K. Choi, None

    H. Y. Kim, None

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