1759. Hospitalization among Persons with Chronic Hepatitis C Virus Infection in the United States: The Chronic Hepatitis Cohort Study (CHeCS), 2006-2010
Session: Poster Abstract Session: Viral Infections; Pathogenesis and Epidemiology
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
Background: Rates of hospitalization in persons living with hepatitis C virus (HCV) infection are increasing and the burden of HCV on the healthcare system continues to grow as the infected population ages. The objective of this study was to describe the rate and average duration of hospital admissions by demographic factors among a cohort of persons with chronic HCV.

Methods: We retrospectively analyzed HCV hospitalizations during 2006-2010 in the CHeCS, an observational cohort study created to assess the natural history and clinical encounters of chronic viral hepatitis in the United States.  CHeCS collects demographic and clinical information from patients diagnosed with chronic HCV at four integrated health care systems in Detroit, MI; Danville, PA; Portland, OR; and Honolulu, HI. 

Results: Among 11,029 patients with chronic HCV infection, 4,616 or 42% (average 8% per year) were hospitalized at least once during 2006-2010. Overall, the proportion ever hospitalized was higher for males than females (43% vs. 41%), for those aged ≥45 years than 18–44 years (44% vs. 37%), and for African Americans (59%) than people of other races (Hispanic: 40%; White: 39%; Asian: 36%).  The overall mean length of hospital stay was 2.61 days per person per year (range 2.19–3.23) and was longer for males than females (2.79 vs. 2.42 days), for African Americans (4.90 days) than people of other races (White: 2.05 days; Asian: 1.89 days; Hispanic: 1.87 days), and for those aged ≥45 years than 18–44 years (2.72 vs. 2.43 days). 

Conclusion: Male sex, age ≥45 years and African American race experienced higher rates of hospital admission and longer hospital stays. The demographic and hospitalization data from CHeCS highlight the substantial US health burden from chronic HCV, particularly among persons older than age 45 years.

Gemechu Gerbi, MSc, PhD1, Jian Xing, PhD2, Loralee Rupp, MS, MSE3, Stuart Gordon, MD3, Joseph A. Boscarino, PhD, MPH4, Mark Schmidt, PhD, MPH5, Vinutha Vijayadeva, MBBS, MPH, PhD6, Anne Moorman, BSN, MPH1, Scott Holmberg, MD, MPH2 and Fujie Xu, MD, PhD7, (1)Centers for Disease Control and Prevention, Atlanta, GA, (2)Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, (3)Henry Ford Health System, Detroit, MI, (4)Geisinger Center for Health Research, Danville, PA, (5)Oregon Department of Human Services, Portland, OR, (6)Kaiser Permanente Hawaii, Honolulu, HI, (7)Division of Viral Hepatitis, Division of Viral Hepatitis, Atlanta, GA

Disclosures:

G. Gerbi, None

J. Xing, None

L. Rupp, None

S. Gordon, None

J. A. Boscarino, None

M. Schmidt, None

V. Vijayadeva, None

A. Moorman, None

S. Holmberg, None

F. Xu, None

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