1622. Impact of intensive infection control team activities on the acquisition of methicillin-resistant Staphylococcus aureus, drug-resistant Pseudomonas aeruginosa and the incidence of Clostridium difficile-associated disease
Session: Poster Abstract Session: Multidrug-Resistant Gram Negative Rods
Saturday, October 5, 2013
Room: The Moscone Center: Poster Hall C
Background: The transmission of multidrug-resistant organisms (MDROs) is an emerging problem in acute healthcare facilities. To reduce this transmission, we have introduced intensive infection control team (ICT) activities and investigated the impact of their introduction.

Methods: This study was conducted at a single teaching hospital from April 1, 2010, to March 31, 2012. During the intervention period, all carbapenem use was monitored by the ICT and doctors using carbapenems inappropriately were individually instructed. Information related to patients with newly identified MDROs was provided daily to the ICT and instructions on the appropriate infection control measures for MDROs were given immediately with continuous monitoring. Medical records of newly hospitalized patients were reviewed daily to check previous microbiological results and infection control intervention by the ICT was also performed for patients with a previous history of MDROs.

Results: Compared with the pre-intervention period, the antimicrobial usage density of carbapenems decreased significantly (28.5 vs. 17.8 defined daily doses/1000 inpatient-days; p<0.001) and the frequency of use of sanitary items, especially the use of aprons, increased significantly (710 vs. 1854 pieces/1000 inpatient-days; p<0.001). The number of cases with hospital-acquired MRSA (0.66 vs. 0.29 cases/1000 inpatient-days; p<0.001), hospital-acquired drug-resistant Pseudomonas aeruginosa (0.23 vs. 0.06 cases/1000 inpatient-days; p=0.006) and nosocomial Clostridium difficile-associated disease (0.47 vs. 0.11 cases/1000 inpatient-days; p<0.001) decreased significantly during the intervention period.

Conclusion: Our study showed that proactive and continuous ICT interventions were effective for reduction of MDRO transmission.

Hiromichi Suzuki, MD1, Junko Senda2, Yasuharu Tokuda, MD, MPH3, Keita Yamashita4, Noriko Kotaki2, Hiroko Ishihara2 and Hiroichi Ishikawa, MD, PhD5, (1)Clinical Laboratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan, (2)Department of Infection Control, Tsukuba Medical Center Hospital, Tsukuba, Japan, (3)Department of Medicine, Mito Kyodo General Hospital, University of Tsukuba, Mito, Japan, (4)Department of Clinical Laboratory, Tsukuba Medical Center Hospital, Tsukuba, Japan, (5)Department of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan

Disclosures:

H. Suzuki, None

J. Senda, None

Y. Tokuda, None

K. Yamashita, None

N. Kotaki, None

H. Ishihara, None

H. Ishikawa, None

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