Methods: A retrospective chart review was conducted on a cohort of HIV-infected patients followed in the HIV clinic at Louis Stokes Cleveland Department of Veterans Affairs Medical Center, prescribed both ART and non-ART medications for more than 365 days continuously by ID clinic provider between 1/1/2011 and 12/31/2012. Measures of medication adherence, calculated by proportion of days covered (PDC) based on prescription date and days of medication supply, were compared between ART and non-ART medications.
Results: Total 458 ART and 667 non-ART medications were included from 171 patients (162 men and 9 women, mean age 54.6). A paired-samples t-test comparing means of ART and non-ART medications of each patient showed a significant difference in PDC of ART (mean 85.8, SD 17.8) and PDC of non-ART medications (mean 77.0, SD 18.0), conditions; t (170), p < 0.001. Mean difference of 8.8% in PDC suggests non-ART medications covered 32.1 days less than ART in 365-days observation period. Age, medication copayment exemption status, history of depression, substance abuse, alcohol abuse were not correlated with difference in PDC of non-ART medications and ART by multiple linear regression. Mean PDC of major non-ART medications are; multivitamin 75.6% (n=57), lisinopril 85.8% (n=46), hydrochlorthiazide 89.5% (n=38), omeprazole 74.3% (n=31), pravastatin 80.6% (n=23), citalopram 76.2% (n=19), and hydrochlorthiazide/lisinopril 85.4% (n=19).
Conclusion: PDC of non-ART medications was lower than PDC of ART in a HIV clinic in VA by 8.8%. Patients who are otherwise adherent to their ART are less adherent with their non-ART medications. Interventions to improve medication adherence should also include non-ART medications in addition to ART.
C. Burant, None
A. Hirsch, None